SYT Break Probe

FONC-111

Synovial sarcomas account for up to 10% of soft-tissue sarcomas, typically arising in the para-articular regions in adolescent and young adults. A characteristic SYT-SSX fusion gene resulting from the chromosomal translocation t(X;18)(p11;q11) is detectable in 90% of synovial sarcomas suggesting this is the primary causal event in the sarcoma. The translocation fuses SYT to either of two highly homologous genes at Xp11 or SSX1. SYT-SSX1 and SYT-SSX2 are thought to disrupt transcription and the expression of specific target genes. A break or split probe for SYT is best used to analyze translocation of the SYT (SS18) gene.

10 Tests

Red/Green

Human

18q11

For Research Use Only. Not for use in diagnostic procedures.

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