Synovial sarcomas account for up to 10% of soft-tissue sarcomas, typically arising in the para-articular regions in adolescent and young adults. A characteristic SYT-SSX fusion gene resulting from the chromosomal translocation t(X;18)(p11;q11) is detectable in 90% of synovial sarcomas suggesting this is the primary causal event in the sarcoma. The translocation fuses SYT to either of two highly homologous genes at Xp11 or SSX1. SYT-SSX1 and SYT-SSX2 are thought to disrupt transcription and the expression of specific target genes. A break or split probe for SYT is best used to analyze translocation of the SYT (SS18) gene.
For Research Use Only. Not for use in diagnostic procedures.
Store at minus 20 centigrade
If you use this products in your scientific publication, it should be cited in the publication as: Creative Bioarray cat no. If your paper has been published, please click here to submit the Pub Med ID of your paper to get a coupon.