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Psoriasis

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Psoriasis

Psoriasis is a chronic inflammatory and proliferative skin disease that affects 2-3% of the population in western countries and an estimated 80 million people worldwide. The disease causes disfiguration in 10- 30% of cases and arthiritis in 10-15% of patients. Although attempts are made to model aspects of psoriasis in animals, none of the models reproduce the complex psoriatic phenotypes that are observed in humans. The availability of an in vitro psoriasis model to screen candidate drugs and to gain a better understanding of the biological mechanisms involved in psoriatic disease would be valuable.

Creative Bioarray provides in vitro Psoriasis skin Model (psoriatic tissue equivalent, PTE) by co-culturing of keratinocytes, fibroblasts, dendritic cells, and T-cells, and offers our customer in vitro pharmacology assays and compound testing service such as histology, ultrastructure, cytokine release, and protein expression of the Psoriasis skin Model, dedicating to the evaluation of pharmacological efficacy of your products.

Psoriasis

Your needs

  • Need to find ready-to-use in vitro Psoriasis Skin Model
  • To evaluation of pharmacological efficacy (screening, profiling, proof-of-concept) of your products (APIs, biosimilars, formulations, medical devices)
  • Need a customized in vitro efficacy tests related to skin efficacy

Our Capability

3D skin models available

Screening assays available

  • Evaluating pharmacological efficacy
  • Compound screening and profiling related to Psoriasis

Endpoint

  • Immune response (Th17/Th22 cytokine release)
  • Induction in keratinocytes (or reconstructed epidermis) of a psoriasis-like profile by cytokines
  • Production of chemokines, antimicrobial peptides (AMPs) and expression of epidermal differentiation markers
  • Specific marker analysis by immunoassays or RT-qPCR

Techniques

  • qPCR, qPCRarray, RT-PCR
  • Epidermal separation
  • Immunofluorescence
  • RNA extraction
  • ELISA
  • Protein extraction

Study Examples

Psoriasis Fig.1 Representative photomicrographs of immunohistochemical staining showing the expression of differentiation markers in control vs. psoriasis skin model under different treatment conditions.

Psoriasis Fig.2 Cytokines expressions of in vitro psoriasis skin model under treatment of different compounds

Related products and services

Choose our models to perform screening assays in house, or choose our assays and services directly!!

Call us today at 631-626-9181, or email us at for a technical supports if any questions! Our customer service representatives are available 24hr a day! We thank you for choosing Creative Bioarray services!

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CONTACT US USA
45-1 Ramsey Road, Shirley, NY 11967, USA
Tel: 1-631-626-9181
Fax: 1-631-614-7828
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Europe
Tel: 44-207-097-1828
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