Stem Cell Research
What is a Stem Cell?
A stem cell is a cell with the unique ability to develop into specialized cell types in the body. Stem cells provide new cells for the body as it grows, and replace specialized cells that are damaged or lost. They have two unique properties: They can divide over and over again to produce new cells; As they divide, they can change into the other types of cell that make up the body. In the future, they may be used to replace cells and tissues that have been damaged or lost due to disease.
What can Stem Cells do?
- To be regenerative medicine for cell transplantation
- To be models for disease mechanism study
- To be used in pre-clinical research of drug development
Creative Bioarray is an experienced and outstanding provider of stem cell research service. We are dedicated to providing detailed data and comprehensive service for your scientific research, and we are pleased to use our extensive experience and advanced platform to offer the best service to satisfy each demand from our customers.
Creative Bioarray provides stem cell research services as follows (including but not limited to):
Stem Cell Line Generation
Stem cells originate from two main sources: adult body tissues and embryos. Scientists are also working on ways to develop stem cells from other cells, using genetic "reprogramming" techniques. However, because utilization of embryos in scientific research faces unavoidably ethical issues, scientists and researchers are paying more attention on induced Pluripotent Stem Cells (iPSCs), which are generated by somatic cells after reprogramming.
Stem Cell Characterization
In stem cell research, there is a challenging but necessary step to validate cells throughout the whole experiments, which is dependent on tools and strategies to distinguish stem cells from a heterogeneous cellular population. Specifically, cellular, molecular, and functional assay tools are required for stem cell characterization.
Stem Cell Differentiation
Stem cell differentiation is the process by which a more specialized cell is formed from a stem cell, leading to loss of some of the stem cell's developmental potential, and it occurs during development of an organism to produce new specialized cells, and also in adults to replenish cells that are lost. Currently, scientists are working on methods to effectively differentiate stem cells into functional specialized cells.
Stem Cell Assay Development and Screening
Stem cells or stem cell-derived downstream cells are the best choice to establish cell models to evaluate new compounds because they are patient-matched. Creative Bioarray provides customers with comprehensive stem cell assay development and screening service, such as: cell viability assay, proliferation, apoptosis, ion transport, pathway signaling, gene expression, protein expression, and post-translational modifications.
CRISPR/Cas9 for iPSC
A major barrier in the field of iPSC-based disease modeling relies on discriminating between the effects of the causative mutation and the genetic background of these cells. In the past decade, researchers have made great improvement in genome editing techniques, with one of the latest being CRISPR/Cas9, which is using a single non-sequence specific protein combined with a small guiding RNA molecule, this state-of-the-art approach enables modifications of genes with high efficiency and accuracy.
Customized iPSC Services
Diverse reprogramming factors, starting cell types, and delivery techniques determine different iPSC lines with little deviation, such as different delivery techniques: lentivirus, retrovirus, and Sendai virus, lead different iPSC lines. Creative Bioarray provides customers with various materials for iPSC research to satisfy their demands.
If you have any special need in stem cell research, do not hesitate to contact us for this special service. Please let us know what you need and we will accommodate you. We are looking forward to working with you in the future.
