Type 1 Diabetes Mellitus Model

Type 1 diabetes is an autoimmune disease characterized by complete insulin deficiency. With the development of economy and the improvement of people's living standard, the morbidity and mortality are increasing year by year. The causative factors of Type 1 diabetes mainly include genetic susceptibility, immunologic dysregulation and exposure to environmental triggers. But the etiology of type 1 diabetes remains unclear. At present, various animal models including spontaneously developing strains, chemical-induced strains and creating diabetes-prone species through gene transfer techniques are used to study Type 1 diabetes.

Creative Bioarray focuses on drug research and development services and helps customers assess/evaluate the drug efficacy and study the associated pathological mechanisms of T1DM by Type 1 diabetes mellitus model.

Type 1 diabetes animal models include but not limited to:

• Chemical-induced Type 1 Diabetes Models
• Streptozotocin-induced Diabetes Mellitus Model
• Alloxan-induced Type 1 Diabetes Model
• Transgenic Models
• Surgical Models

Species available

• Rat
• Mouse
• Rabbit
• Dog
• Pig

Our capabilities

• The transparency of the lens was observed using a slit-lamp and anterior segment in both eyes of rat were imaged using an anterior segment camera system.
• We test the levels of advanced glycation end products (AGEs), MDA, GSH as well as the activities of SOD and CAT by Elisa.

Assays available

• Evaluation of progression of cataract
• Biochemical analysis
• Pathological evaluation of lens

With extensive experience in the field of T1DM, we are confident to help you overcome any upcoming challenges. Our experts are fully capable of customizing our protocols and assays to meet your specific needs. With our help, we wish to facilitate your research with high efficiency.

Study examples

Figure. 1. Quantitive representation of cataract progression in each group with time. Stage of cataract in each group was averaged at a given time.

Figure. 2. Hematoxylin-eosin staining of rat lens paraffin sections: (A) organized monolayer of cuboidal lens epithelial cells in the C group (×400); (B) multiple layers of lens epithelial cells can be seen in the DM group (×400); (C) lens epithelial cells are still in a monolayer in the AL group with slight disorganization (×400); (D) lens section from the C group (×200); (E) DM group (×200); (F) DM+AL group (×200).

Quotation and ordering

If you have any special needs or questions regarding our services, please feel free to contact us at 631-626-9181 or info@creative-bioarray.com. We look forward to cooperating with you in the future.

Reference

1. Yang, Ming, et al. "Effect of astaxanthin on metabolic cataract in rats with type 1 diabetes mellitus." Experimental and Molecular Pathology (2020): 104372.