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Type 1 diabetes is an autoimmune disease characterized by complete insulin deficiency. With the development of economy and the improvement of people's living standard, the morbidity and mortality are increasing year by year. The causative factors of Type 1 diabetes mainly include genetic susceptibility, immunologic dysregulation and exposure to environmental triggers. But the etiology of type 1 diabetes remains unclear. At present, various animal models including spontaneously developing strains, chemical-induced strains and creating diabetes-prone species through gene transfer techniques are used to study Type 1 diabetes.
Creative Bioarray focuses on drug research and development services and helps customers assess/evaluate the drug efficacy and study the associated pathological mechanisms of T1DM by Type 1 diabetes mellitus model.
Type 1 diabetes animal models include but not limited to:
With extensive experience in the field of T1DM, we are confident to help you overcome any upcoming challenges. Our experts are fully capable of customizing our protocols and assays to meet your specific needs. With our help, we wish to facilitate your research with high efficiency.
Figure. 1. Quantitive representation of cataract progression in each group with time. Stage of cataract in each group was averaged at a given time.
Figure. 2. Hematoxylin-eosin staining of rat lens paraffin sections: (A) organized monolayer of cuboidal lens epithelial cells in the C group (×400); (B) multiple layers of lens epithelial cells can be seen in the DM group (×400); (C) lens epithelial cells are still in a monolayer in the AL group with slight disorganization (×400); (D) lens section from the C group (×200); (E) DM group (×200); (F) DM+AL group (×200).
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Yang, Ming, et al. "Effect of astaxanthin on metabolic cataract in rats with type 1 diabetes mellitus." Experimental and Molecular Pathology (2020): 104372.
Metabolic Disease Models:
Type 1 Diabetes Mellitus Model: