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Isoproterenol-induced Heart Failure Model

Isoproterenol, a nonselective beta-adrenergic agonist, cause cardiac injury and is commonly used in the study of heart disease. These models are classified into acute and chronic heart failure depending on the dose and duration of isoproterenol administration. Isoproterenol induced acute heart failure is a model characterized by acute apical segment ventricular dysfunction, simulating stress-induced cardiomyopathy (SIC) in human. Besides, the chronic model mimics advanced heart failure in humans. These models provides tools to study structural and functional adaptation of myocardium during the progression of heart failure.

Creative Bioarray specializes in providing customized pharmacodynamic research services to help customers assess the efficacy of drug candidates and study the associated pathological mechanisms through isoproterenol-induced heart failure model.

Acute and chronic isoproterenol modelsFigure. 1. Acute and chronic isoproterenol models

Species available

  • Mouse
  • Rat

Our Capabilities

  • We detect changes in myocardial morphology by H&E staining and so on.
  • We evaluate left ventricular internal diameters in diastole (LVIDD, mm), left ventricular internal diameters in systole (LVIDS, mm) and left ventricular ejection fraction (EF, %) and left ventricular fractional shortening by Echocardiography.

Assays available

  • Echocardiography
  • Transmission Electron Microscope (TEM)
  • Histopathological evaluation
  • Biochemical analysis

With extensive experience in the field of cardiovascular diseases, we are confident to help you overcome any upcoming challenges. Our experts are fully capable of customizing our protocols and assays to meet your specific needs. With our help, we wish to facilitate your research with high efficiency.

Study examples

Effect of OMT on cardiac histopathological changes of ISO-induced heart failure rats (H&E staining 200×). (A) Control. (B) OMT 100 mg/kg. (C) Isoproterenol 5 mg/kg. (D) OMT 100 mg/kg + isoproterenol. (E) OMT 50 mg/kg + isoproterenol.Figure. 2. Effect of OMT on cardiac histopathological changes of ISO-induced heart failure rats (H&E staining 200×). (A) Control. (B) OMT 100 mg/kg. (C) Isoproterenol 5 mg/kg. (D) OMT 100 mg/kg + isoproterenol. (E) OMT 50 mg/kg + isoproterenol.

Representative Van Gieson-stained sections of the cardiac apex (100×). (A) Control. (B) OMT 100 mg/kg. (C) Isoproterenol 5 mg/kg. (D) OMT 100 mg/ kg + isoproterenol. (E) OMT 50 mg/kg + isoproterenol. Red indicates fibrotic regions.(For interpretation of the references to colour in this figure legend,the reader is referred to the web version of this article.)Figure. 3. Representative Van Gieson-stained sections of the cardiac apex (100×). (A) Control. (B) OMT 100 mg/kg. (C) Isoproterenol 5 mg/kg. (D) OMT 100 mg/ kg + isoproterenol. (E) OMT 50 mg/kg + isoproterenol. Red indicates fibrotic regions.(For interpretation of the references to colour in this figure legend,the reader is referred to the web version of this article.)

Representative raw tracings of M-mode echocardiographyFigure. 4 Representative raw tracings of M-mode echocardiography

Quotation and ordering

If you have any special needs or questions regarding our services, please feel free to contact us. We look forward to cooperating with you in the future.

References

  1. Zhou R, et al. Oxymatrine attenuated isoproterenol-induced heart failure in rats via regulation of COX-2/PGI2 pathway[J]. Biomedicine & Pharmacotherapy, 2016:S0753332216311386.

  2. Rui, He, et al. MiR-1a-3p mitigates isoproterenol-induced heart failure by enhancing the expression of mitochondrial ND1 and COX1.[J]. Experimental cell research, 2019.

For research use only. Not for any other purpose.