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Obesity is a chronic disease commonly caused by a combination of genetic, nutritional, and environmental factors. It is a risk factor for cardiovascular disease, diabetes mellitus, fatty liver disease, cancers, and asthma. So far, it has become the most growing public health issues. High fat diet-induced obesity is a model that simulates the features of obesity in human and it is suitable for the development of novel preventions and/or treatments.
Creative Bioarray focuses on drug research and development services and can help customers with evaluating the efficacy of drug candidates and studying the associated pathological mechanisms of obesity.
With extensive experience in the field of obesity, we are confident to help you overcome any upcoming challenges. Our experts are fully capable of customizing our protocols and assays to meet your specific needs. With our help, we wish to facilitate your research with high efficiency.
Figure. 1. Representative micrographs from the heart exhibiting the protective effect of methanol M. oleifera leaf extract (MEML) on high-fat diet-induced cardiac injury in rats. (A) Control groups showing normal cardiac architecture. (B) High-fat diet-treated group showing anarchized myocardial fibers associated with interstitial edema and inflammatory cellule collections. (C) High-fat diet group received MEML (200 mg/kg) showing repair in the histological sections. (D) High-fat diet group treated with MEML (400 mg/kg) showing normal structure almost similar to control. Heart sections were stained using hematoxylin-eosin method.
Figure. 2. Effect of morin on (A) Body weight (at the end of study) (B) Liver weight / Body weight ratio (C) Retroperitoneal fat content
Figure. 3. Effect of Morin on histology of isolated rat aorta. Histological sections of the aortae of all animals were stained with hematoxylin and eosin (H & E) to study their general structures, whereas to investigate collagen and elastic fibers sections, van Gieson and Verhöeff's stains, respectively, were used (x30).
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Metabolic Disease Models: