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Potassium Oxonate-Induced Hyperuricaemia Model

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Hyperuricemia is a main cause of diabetes, metabolic syndrome and chronic kidney disease and it is characterized by abnormally high levels of plasma uric acid (UA) in human. Xanthine oxidase (XOD) plays an important role during the formation of UA and can transform xanthine and hypoxanthine into it. Both excessive consumption of purine foods and a lack of genetic enzymes can cause hyperuricemia.

Potassium oxonate (PO) is a kind of triazabenzene compound and can inhibit the activity of uricase, leading to a rise in the level of UA. PO-induced hyperuricemia is an animal model that mimic the increase of UA in hyperuricemia patients. This model is usually used by drug developers and biomedical scientists to study the pathogenesis of hyperuricemia.

Creative Bioarray, with a prestigious team in the industry, focuses on providing customized experiment services to help customers assess the efficacy of compounds and study the associated pathological mechanisms of Type 1 diabetes through PO-induced hyperuricemia model.

Species available

  • Rat
  • Mouse

Our capabilities

  • Rodents are administrated by intraperitoneal injection, gavage etc.
  • We detect the degree of kidney injury by H&E staining.
  • We test the activities of MDA, SOD and GSH-PX by Elisa.

Assays available

  • Biochemical analysis 
  • Pathological evaluation

With extensive experience in the field of hyperuricaemia, we are confident to help you overcome any upcoming challenges. Our experts are fully capable of customizing our protocols and assays to meet your specific needs. With our help, we wish to facilitate your research with high efficiency.

Study examples

Effects of CUR on hyperuricemia and kidney injury in hyperuricemic mice. (A) The level of serum UA. (B) The level of serum CRE. (C) The level of serum BUN. Figure. 1. Effects of CUR on hyperuricemia and kidney injury in hyperuricemic mice. (A) The level of serum UA. (B) The level of serum CRE. (C) The level of serum BUN.

Effect of CUR on kidney pathological changes for PO-induced hyperuricemic mice. (A) The representative pictures of kidney histopathology (200×). (B) Affected renal (%) (n = 3).Figure. 2. Effect of CUR on kidney pathological changes for PO-induced hyperuricemic mice. (A) The representative pictures of kidney histopathology (200×). (B) Affected renal (%) (n = 3).

Effects of CUR on the levels of pro-inflammatory cytokines.Figure. 3. Effects of CUR on the levels of pro-inflammatory cytokines.

Quotation and ordering

If you have any special needs or questions regarding our services, please feel free to contact us at 631-626-9181 or . We look forward to cooperating with you in the future.

Reference

  1. Chen Y, et al. Curcumin attenuates potassium oxonate-induced hyperuricemia and kidney inflammation in mice[J]. Biomedicine & Pharmacotherapy, 2019, 118: 109195.


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