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  5. Chronic Unpredictable Mild Stress (CUMS) Model

Chronic Unpredictable Mild Stress (CUMS) Model

The Chronic Unpredictable Mild Stress (CUMS) Model is a well-established and widely validated animal model for studying depression-like behaviors and the pathophysiology of mood disorders. By exposing animals to a variety of mild and unpredictable stressors over a period of time, the CUMS model mimics chronic stress conditions in humans and induces behavioral and neurobiological changes relevant to major depressive disorder (MDD).

At Creative Bioarray, we provide highly reproducible and customizable CUMS modeling services in mice, enabling preclinical evaluation of antidepressant candidates and central nervous system (CNS)-targeted therapies.

Creative Bioarray's Depression Models

Animal Species

Mouse

Modeling Method

Animals are subjected to 1-2 mild stressors per day, for a continuous period of 3 to 6 weeks. These stressors include:

  • Food or water deprivation
  • Cage tilt at 45°
  • Wet bedding
  • Cold swim
  • Hot swim
  • Restraint stress
  • Tail pinch
  • Unpredictable shock

1.Fig. 1: CUMS mouse model induction workflow.

Fig. 1: Modeling method of CUMS model in Creative Bioarray

Endpoints

  • Sucrose preference test (SPT)
  • Tail suspension test (TST)
  • Forced swim test (FST)
  • Open field test
  • Elevated plus maze (EPM)
  • Light/Dark box test
  • Other customized endpoints

Applications

  • Evaluation of antidepressant efficacy
  • Mechanism of action studies for CNS drugs
  • Research on stress-induced neuroplasticity
  • Assessment of anti-anxiety and neuroprotective agents
  • Behavioral pharmacology screening

Example Data

Fig. 2: Behavioral testing for depression-like phenotypes in mice.

Fig. 2: Behavioral assessments of depressive-like behaviors in mice. (Zhang et al., 2021)

Quotation and Ordering

If you have any special needs or questions regarding our depression models, please do not hesitate to contact us or submit an inquiry to us directly. We look forward to cooperating with you in the future.

Reference

  1. Zhang, C.L., et al. Fluoxetine ameliorates depressive symptoms by regulating lncRNA expression in the mouse hippocampus. Zool Res. 2021;42(1):28-42.

For research use only. Not for any other purpose.

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