Neoplasms FISH Analysis
Creative Bioarray offers a wide menu of probes for fluorescent in situ hybridization (FISH) testing. FISH can help identify subtle or sub-microscopic structural rearrangements, variant chromosomes, and low-frequency abnormalities not readily detectable by class cytogenetics.
Panels can be customized upon request- please inquire for more details.
With many years of experience and in-depth knowledge, Creative Bioarray can use fluorescence in situ hybridization (FISH) to do the FISH analysis for you. We guarantee the speed, quality and cost of our service.
Neoplastic FISH Panel
| Panel | Probe | Target Abnormality |
| ALL panel | IGH/MYC/CEP8 | t(8;14)(q24;q32), trisomy 8 |
| CDKN2A/CEP9 | 9p21 (p16) deletion | |
| BCR/ABL1 | t(9;22)(q34;q11.2) | |
| MLL | 11q23 rearrangements | |
| TEL/AML1 | t(12;21)(p13;q22) | |
| AML panel | D7S522/D7Z1 | 7q31 deletion/ monosomy 7 |
| D8Z2 | Trisomy 8 | |
| AML1/ETO | t(8;21)(q21.3;q22) | |
| MLL | 11q23 rearrangements | |
| PML/RARA | t(15;17)(q24;q21) | |
| CBFB | t(16;16)/ inv(16)(q22) | |
| CLL panel | ATM | 11q22.3 deletion |
| D12Z3 | Trisomy 12 | |
| DLEU1/LAMP1 | 13q14 deletion/ monosomy 13 | |
| TP53 | 17p13.1 deletion | |
| IGH/CCND1 | t(11;14)(q13;q32) | |
| CML panel | BCR/ABL1 | t(9;22)(q34;q11.2) |
| 9q34 | 9q34 deletion | |
| Eosinophilia panel | PDGFRA-FIP1L1 | 4q12 deletion/rearrangement |
| PDGFRB | 5q33 rearrangements | |
| FGFR1 | 8p11.23-p11.22 rearrangements | |
| MDS panel | EGR1/D5S23 | 5q31 deletion/ monosomy 5 |
| D7S522/D7Z1 | 7q31 deletion/ monosomy 7 | |
| D8Z2 | Trisomy 8 | |
| D20S108 | 20q12 deletion | |
| MM panel | CKS1B/CDKN2C | Gain of 1q21.3 / loss of 1p32.3 |
| IGH/FGFR3 | t(4;14)(p16;q32) | |
| DLEU1/LAMP1 | 13q14 deletion/ monosomy 13 | |
| TP53 | 17p13.1 deletion | |
| 5p15 / 9q22 / 15q22 | Hyperdiploidy for chromosomes 5, 9, 15 | |
| IGH/CCND1 | t(11;14)(q13;q32) | |
| IGH Breakapart | 14q32 rearrangements | |
| IGH/MAF | t(14;16)(q32;q23) | |
| IGH/MAFB | t(14;20)(q32;q12) | |
| MPD panel | PDGFRA-FIP1L1 | 4q12 deletion/rearrangement |
| PDGFRB | 5q33 rearrangements | |
| D8Z2 | Trisomy 8 | |
| BCR/ABL1 | t(9;22)(q34;q11.2) | |
| DLEU1/LAMP1 | 13q14 deletion/ monosomy 13 | |
| D20S108 | 20q12 deletion | |
| NHL panel | BCL6 | 3q27 rearrangements |
| MYC BAP | 8q24 rearrangements | |
| IGH/CCND1 | t(11;14)(q13;q32) | |
| BIRC3/MALT1 | t(11;18)(q21;q21) | |
| IGH/BCL2 | t(14;18)(q32;q21) |
Probes that can be added to customize panel upon request
Standard Analysis:
For each FISH probe, a minimum of 200 interphase cells are analyzed for abnormal signal patterns. FISH on metaphase cells can also be performed if requested.
Features
- High accuracy and sensitively
- Fast turnaround time
- Competitive pricing
Quotations and ordering
Our customer service representatives are available 24hr a day! We thank you for choosing Creative Bioarray at your preferred Neoplasms FISH Analysis.
References
- Peterson J F, et al. Elucidating a false-negative MYC break-apart fluorescence in situ hybridization probe study by next-generation sequencing in a patient with high-grade B-cell lymphoma with IGH/MYC and IGH/BCL2 rearrangements[J]. Molecular Case Studies, 2019, 5(3): a004077.
- Zhao L, et al. Interphase fluorescence in situ hybridization analysis: A study using centromeric probes 7, 8, and 12[J]. Annals of Clinical & Laboratory Science, 1998, 28(1): 51-56.
- Haferlach, C., et al. "Mutations of the TP53 gene in acute myeloid leukemia are strongly associated with a complex aberrant karyotype." Leukemia 22.8 (2008): 1539-1541.
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