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Neoplasms FISH Analysis

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Creative Bioarray offers a wide menu of probes for fluorescent in situ hybridization (FISH) testing. FISH can help identify subtle or sub-microscopic structural rearrangements, variant chromosomes, and low-frequency abnormalities not readily detectable by class cytogenetics.

Panels can be customized upon request- please inquire for more details.

With many years of experience and in-depth knowledge, Creative Bioarray can use fluorescence in situ hybridization (FISH) to do the FISH analysis for you. We guarantee the speed, quality and cost of our service.

Neoplastic FISH Panel

PanelProbeTarget Abnormality
ALL panelIGH/MYC/CEP8t(8;14)(q24;q32), trisomy 8
CDKN2A/CEP99p21 (p16) deletion
BCR/ABL1t(9;22)(q34;q11.2)
MLL11q23 rearrangements
TEL/AML1t(12;21)(p13;q22)
AML panelD7S522/D7Z17q31 deletion/ monosomy 7
D8Z2Trisomy 8
AML1/ETOt(8;21)(q21.3;q22)
MLL11q23 rearrangements
PML/RARAt(15;17)(q24;q21)
CBFBt(16;16)/ inv(16)(q22)
CLL panelATM11q22.3 deletion
D12Z3Trisomy 12
DLEU1/LAMP113q14 deletion/ monosomy 13
TP5317p13.1 deletion
IGH/CCND1t(11;14)(q13;q32)
CML  panelBCR/ABL1t(9;22)(q34;q11.2)
9q349q34 deletion
Eosinophilia panelPDGFRA-FIP1L14q12 deletion/rearrangement
PDGFRB5q33 rearrangements
FGFR18p11.23-p11.22 rearrangements
MDS  panelEGR1/D5S235q31 deletion/ monosomy 5
D7S522/D7Z17q31 deletion/ monosomy 7
D8Z2Trisomy 8
D20S10820q12 deletion
MM panelCKS1B/CDKN2CGain of 1q21.3 / loss of 1p32.3
IGH/FGFR3t(4;14)(p16;q32)
DLEU1/LAMP113q14 deletion/ monosomy 13
TP5317p13.1 deletion
5p15 / 9q22 / 15q22Hyperdiploidy for chromosomes 5, 9, 15
IGH/CCND1t(11;14)(q13;q32)
IGH Breakapart14q32 rearrangements
IGH/MAFt(14;16)(q32;q23)
IGH/MAFBt(14;20)(q32;q12)
MPD panelPDGFRA-FIP1L14q12 deletion/rearrangement
PDGFRB5q33 rearrangements
D8Z2Trisomy 8
BCR/ABL1t(9;22)(q34;q11.2)
DLEU1/LAMP113q14 deletion/ monosomy 13
D20S10820q12 deletion
NHL panelBCL63q27 rearrangements
MYC BAP8q24 rearrangements
IGH/CCND1t(11;14)(q13;q32)
BIRC3/MALT1t(11;18)(q21;q21)
IGH/BCL2t(14;18)(q32;q21)

Probes that can be added to customize panel upon request

Standard Analysis:

For each FISH probe, a minimum of 200 interphase cells are analyzed for abnormal signal patterns. FISH on metaphase cells can also be performed if requested.

Features

  • High accuracy and sensitively
  • Fast turnaround time
  • Competitive pricing

Quotations and ordering

Call us today at 631-626-9181, or email us at for a quotation or if any questions! Our customer service representatives are available 24hr a day! We thank you for choosing Creative Bioarray at your preferred Neoplasms FISH Analysis.

References

  1. Peterson J F, et al. Elucidating a false-negative MYC break-apart fluorescence in situ hybridization probe study by next-generation sequencing in a patient with high-grade B-cell lymphoma with IGH/MYC and IGH/BCL2 rearrangements[J]. Molecular Case Studies, 2019, 5(3): a004077.
  2. Zhao L, et al. Interphase fluorescence in situ hybridization analysis: A study using centromeric probes 7, 8, and 12[J]. Annals of Clinical & Laboratory Science, 1998, 28(1): 51-56.
  3. Haferlach, C., et al. "Mutations of the TP53 gene in acute myeloid leukemia are strongly associated with a complex aberrant karyotype." Leukemia 22.8 (2008): 1539-1541.

For research use only. Not for any other purpose.


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