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The sulforhodamine B (SRB) assay was developed by Skehan and colleagues to measure drug-induced cytotoxicity and cell proliferation for large-scale drug-screening applications. Sulforhodamine B, an anionic aminoxanthene dye, can form an electrostatic complex with the basic amino acid residues of proteins under moderately acid conditions, which provides a sensitive linear response with cell number and cellular protein measured at cellular densities ranging from 1 to 200% of confluence. The SRB assay possesses a nondestructive and indefinitely stable colorimetric end point and the color development is rapid and stable and is readily measured at absorbance between 560 and 580nm. With many practical advances including a favorable signal-to-noise ratio and a resolution of 1000–2000 cells/well, the SRB assay serves as an appropriate and sensitive assay to measure drug-induced cytotoxicity even at large-scale application.
Creative Bioarray Advantages
Figure 1. Graphic determination of IC50
Figure 2. Effects of compounds on cell proliferation
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Cell Line Testing and Assays: