Venous Thrombosis Model

Venous thrombosis (VT) is a common clinical condition worldwide and related to high mortality rate. The etiology of VT is multifactorial and mainly involved with genetics, venous endothelial injury, hypercoagulabilitya and venous stasis. The injury of vein wall, the release of inflammatory cells and coagulation factors as well as their interaction all lead to the occurrence of VT. At present, systemic anticoagulation and catheter-directed thrombolysis are the main strategies to treat venous thrombosis. However, the specific pathogenesis of VT has not been completely understood.

Creative Bioarray specializes in providing customized pharmacodynamic research services to help customers assess the efficacy of drug candidates and study the associated pathological mechanisms through VT models.

Models available

• Ferric chloride induced venous injury
• Inferior vena cava stasis or ligation model
• Electrolytic stimulation model
• Inferior vena cava stenosis model

Species available

• Mouse
• Rat
• Rabbit

Our Capabilities

• We estimate the thrombus size by counting the pathological staining area.

Assays available

• Thrombus weight measurement
• Histopathological evaluation
• Magnetic resonance imaging
• Biochemical analysis

With extensive experience in the field of venous thrombosis, we are confident to help you overcome any upcoming challenges. Our experts are fully capable of customizing our protocols and assays to meet your specific needs. With our help, we wish to facilitate your research with high efficiency.

Study examples

Figure. 1. The inferior vena cava is the most commonly used vessel in the venous thrombosis model. The segment caudal to the left renal vein is used. Anatomical variations in the number of side branches in this area are common.

Figure. 2. Representative micrographs of trans-verse thrombus sections stained with Martius scarlet blue (MSB) at days 1, 7, 14, 21, and 28 post induction. MSB detects collagen (blue), fibrin (red), and erythrocytes (yellow); scale bars, 200 µm (low power) and 25 µm (high power).

Quotation and ordering

If you have any special needs or questions regarding our services, please feel free to contact us at 631-626-9181 or info@creative-bioarray.com. We look forward to cooperating with you in the future.

References

1. Schönfelder, S. Jäckel, P. Wenzel. Mouse models of deep vein thrombosis[J]. Gefässchirurgie, 2017.

2. Grover S P , Evans C E , Patel A S , et al. Assessment of Venous Thrombosis in Animal Models[J]. Arteriosclerosis Thrombosis and Vascular Biology, 2015, 36(2):245.