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Alloxan is a strong oxidant that can rapidly damage pancreatic β-cells and is commonly used in experimental animals to induce insulin-dependent diabetes (type 1). It works by increasing generation of reactive oxygen species from metabolic reactions in the body, together with massive increase of cytosolic calcium concentration.
Alloxan-induced type 1 diabetes is a model which mimics the process or pathological condition of type 1 diabetes in human. Therefore, this model is often used to study the causes and prevention of type 1 diabetes.
Creative Bioarray, with the suitable model for type 1 diabetes, can provide customers with drug testing and pathogenesis research services to assess the efficacy of drug candidates and study the associated mechanisms of type 1 diabetes.
With extensive experience in the field of T1DM, we are confident to help you overcome any upcoming challenges. Our experts are fully capable of customizing our protocols and assays to meet your specific needs. With our help, we wish to facilitate your research with high efficiency.
Figure. 1. FMN increased insulin activity and hepatic glycogen level of mice with type 1 diabetes and did not affect glucagon level of mice with type 1 diabetes. (a) Insulin activity. (b) Glucagon level. (c) Hepatic glycogen level. ##P < 0.01 vs. those in the normal group, **P < 0.01 vs. those in the model group
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Qiu G , et al. Formononetin exhibits anti-hyperglycemic activity in alloxan-induced type 1 diabetic mice[J]. Experimental Biology & Medicine, 2016, 242(2):223-230.
Metabolic Disease Models: