Alloxan-Induced Type 1 Diabetes Model
Alloxan is a strong oxidant that can rapidly damage pancreatic β-cells and is commonly used in experimental animals to induce insulin-dependent diabetes (type 1). It works by increasing generation of reactive oxygen species from metabolic reactions in the body, together with massive increase of cytosolic calcium concentration.
Alloxan-induced type 1 diabetes is a model which mimics the process or pathological condition of type 1 diabetes in human. Therefore, this model is often used to study the causes and prevention of type 1 diabetes.
Creative Bioarray, with the suitable model for type 1 diabetes, can provide customers with drug testing and pathogenesis research services to assess the efficacy of drug candidates and study the associated mechanisms of type 1 diabetes.
Species available
- Rat
- Mouse
- Rabbit
Our capabilities
- We establish alloxan-induced Type 1 diabetes model by tail vein injection.
- We use an electronic scale to weigh the mice at different time points during the drugs administration.
- The insulin activity and hepatic glycogen level in rodents are evaluated by Elisa.
Assays available
- Biochemical analysis
- Pathological evaluation
With extensive experience in the field of T1DM, we are confident to help you overcome any upcoming challenges. Our experts are fully capable of customizing our protocols and assays to meet your specific needs. With our help, we wish to facilitate your research with high efficiency.
Study examples
Figure. 1. FMN increased insulin activity and hepatic glycogen level of mice with type 1 diabetes and did not affect glucagon level of mice with type 1 diabetes. (a) Insulin activity. (b) Glucagon level. (c) Hepatic glycogen level. ##P < 0.01 vs. those in the normal group, **P < 0.01 vs. those in the model group
Quotation and ordering
If you have any special needs or questions regarding our services, please feel free to contact us. We look forward to cooperating with you in the future.
Reference
Qiu G , et al. Formononetin exhibits anti-hyperglycemic activity in alloxan-induced type 1 diabetic mice[J]. Experimental Biology & Medicine, 2016, 242(2):223-230.
