Multiple Sclerosis (MS) Models
Multiple Sclerosis (MS) is a chronic inflammatory disease of the neural central system characterized by demyelination, oligodendrocyte destruction, reactive gliosis and axonal degeneration. It is reported that MS affects an estimated 2.3 million people worldwide. MS can be classified into relapsing-remitting multiple sclerosis (RRMS), secondary progressive multiple sclerosis (SPSM), primary progressive multiple sclerosis (PPMS), and progressive-relapsing multiple sclerosis (RPMS) according to varying degrees of progression and symptoms. Approximately 95% of people with MS are diagnosed with RRMS and PPMS. However, there is still no relable therapy for MS.
Creative Bioarray specializes in providing customized pharmacodynamic research services to help customers assess the efficacy of drug candidates targeting MS and study the associated pathological mechanisms through MS models.
Creative Bioarray provides you with multiple sclerosis (MS) models including but not limited to:
- EAE Models
- EAE induced mouse model
- MOG35-55 EAE in C57BL/6 mice
- EAE induced rat model
- SCH EAE in rats
- Demyelination MS models
- Cuprizone induced mouse model
- Focal LPC-induced rat model
Our capabilities
- We utilize multiple sclerosis (MS) models to test therapeutic candidates against MS.
- We assess the severity of MS through EAE clinical score system.
- We quantitatively assess lymphocyte infiltration, demyelination and axonal damage by Histopathological analysis.
Assays available
- Histopathological evaluation
- SPECT/CT monitoring
- Flow cytometry
- MRI
With extensive experience in the field of MS, we are confident to help you to overcome any upcoming challenges. Our experts are fully capable of customizing our protocols and assays to meet your specific needs. With our help, we wish to facilitate your research with high efficiency.
Study examples
Figure. 1. Representative EAE results. A. Representative picture of an immunized C57BL/6 mouse with EAE symptoms (EAE score 6). B. Representative disease course after immunization over 30 days. Data are shown as mean and standard error of the mean (n = 5)
Quotation and ordering
If you have any special needs or questions regarding our services, please feel free to contact us. We look forward to cooperating with you in the future.
Reference
Bittner S, et al. Myelin Oligodendrocyte Glycoprotein (MOG35-55) Induced Experimental Autoimmune Encephalomyelitis (EAE) in C57BL/6 Mice[J]. Journal of Visualized Experiments, 2014(86).
