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Spontaneously Hypertensive Rat Model

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Spontaneously hypertensive rats (SHRs) are introduced by Okamoto and Aoki and the most commonly used animal model that resemble essential hypertension in human. These rats develop hypertension without any physiological, pharmacological or surgical procedures. The SHRs also develop accompanying cardiovascular disease, stroke and other diseases under specific environmental conditions. Creative Bioarray specializes in providing customized pharmacodynamic research services to help customers assess the efficacy of drug candidates and understand the pathological mechanisms of essential hypertension through spontaneously hypertensive rat model.

Our capabilities

  • We screen novel test compounds targeting hypertension.
  • Blood pressure (BP) was monitored by tail-cuff.

Assays available

  • PK/PD collection
  • Pathological evaluation
  • Cytokine analysis
  • Blood pressure monitoring

With extensive experience in the field of hypertension, we are confident to help you to overcome any upcoming challenges. Our experts are fully capable of customizing our protocols and assays to meet your specific needs. With our help, we wish to facilitate your research with high efficiency.

Study examples

Effects of HXQY decoction on heart structure and blood pressure in obese SHRs.
(A–C) After 8 weeks of treatment, the heart weight index (A) and LVMI (B) in SHRs were measured. The systolic blood pressure of SHRs before and during the 8-week period of drug treatment was measured once per week (C). n = 9 for each group; ※P < 0.05, compared with the control SHR group; #P < 0.05, compared with the Obese SHR group; ✝P < 0.05, compared with the Obese SHR +HXQY group; ‡ P < 0.05, compared with the baseline (0 week).
 Figure. 1. Effects of HXQY decoction on heart structure and blood pressure in obese SHRs.
(A–C) After 8 weeks of treatment, the heart weight index (A) and LVMI (B) in SHRs were measured. The systolic blood pressure of SHRs before and during the 8-week period of drug treatment was measured once per week (C). n = 9 for each group; P < 0.05, compared with the control SHR group; #P < 0.05, compared with the Obese SHR group; P < 0.05, compared with the Obese SHR +HXQY group; ‡ P < 0.05, compared with the baseline (0 week).

Quotation and ordering

If you have any special needs or questions regarding our services, please feel free to contact us at 631-626-9181 or . We look forward to cooperating with you in the future.

Reference

  1. Zhou, X., et al. Huoxue Qianyang decoction ameliorates cardiac remodeling in obese spontaneously hypertensive rats in association with ATF6-CHOP endoplasmic reticulum stress signaling pathway regulation. Biomedicine & Pharmacotherapy, 121, 109518.


Related Sections

Cardiovascular Disease Models:

Animal Models of Hypertension:

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