Cell-based Screening and Profiling Services
- Service Details
- Workflow
- Features
- FAQ
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Cellular response is a crucial step in drug discovery and biomedical research, enabling the identification of therapeutic candidates and the elucidation of biological mechanisms. Traditional methods like biochemical assays and animal models frequently fail to replicate the complexity or translational relevance necessary for human cellular systems.
Our Cell-based Screening and Profiling Services provide end-to-end solutions to support early-stage discovery, target validation and mechanism-of-action studies. By harnessing the power of diverse cell models and cutting-edge assay platforms, we deliver reliable data to drive your research forward with speed and accuracy.
Our Capabilities
- Diverse Cell Types: Primary cells, stem cells, tumor cell lines, immune cells, and engineered drug screening cell models
- 3D Culture Systems: Spheroid models and organoids to better mimic in vivo environments
- 2D and 3D Cell-based Assays: Flexible platforms for various biological investigations
- High-throughput Screening (HTS): Automated platforms for rapid testing of thousands of compounds in diverse cellular models
- High-content Screening (HCS): Multiparametric imaging-based analysis for detailed cellular phenotyping
Our Services
Our Cell-based Screening and Profiling Services are built on a robust phenotypic screening platform designed to assess how compounds, biologics, or genetic interventions affect cellular functions and behaviors. Our in vitro assay services cover a wide spectrum to support early discovery alongside lead optimization and safety assessment.
Phenotypic Screening and Profiling
Measure the efficacy of compounds on key cellular readouts (viability, proliferation, apoptosis, cytotoxicity, morphology, etc.) for identification of bioactive compounds with desired phenotypic response.
Measure cell fate decisions through detection of lineage-specific markers and monitoring the differentiation status in response to various stimuli or conditions, useful in stem cell research, regenerative medicine and developmental biology.
Evaluate the angiogenic potential or inhibition of compounds using validated assays for tube formation, endothelial cell migration and proliferation, for applications in oncology, vascular biology and drug discovery.
Signaling Pathway Profiling
Assess the mechanisms of disease-related signaling pathways and compound target interactions through reporter gene assays and proteomics/transcriptomics-based techniques.
Safety & Toxicity Assessment
Perform early-stage safety assessment by measuring off-target or adverse cellular responses in relevant cell types such as hepatocytes, cardiomyocytes, neurons, etc. to inform risk assessment and candidate selection.
Screen compounds in advanced three-dimensional systems such as organoids or spheroids to provide insights into tissue-like responses, drug penetration and multicellular interactions for a more physiologically relevant evaluation.
Standard Workflow
Step1：Cell Preparation
Culture establishment and quality assessment of validated cellular models, including two-dimensional (2D) monolayers, three-dimensional (3D) spheroids, or organoid systems, optimized for specific experimental protocols.
Step2: Compound Library Selection
Curating and formatting compound libraries supplied by the client or sourced from our in-house collections.
Step3: Compound Treatment
Cells are exposed to compounds under optimized dosing conditions and incubation timelines tailored to the assay type.
Step4: Data Acquisition
Capture of cellular responses using high-throughput or high-content platforms (e.g., imaging, flow cytometry, luminescence).
Step5: Data Analysis & Reporting
In-depth analysis of phenotypic outcomes, statistical interpretation, hit identification, and provision of a structured report.
Features
Extensive Assay Portfolio
Offering a complete spectrum of cellular analyses ranging from fundamental cytotoxicity assessments to sophisticated investigations of intricate signaling pathways and mechanistic studies.
Cutting-edge Technology Platforms
Utilizing state-of-the-art high-content screening (HCS) systems, multi-parameter flow cytometry, and advanced multiplex assay technologies to deliver high-resolution, multi-dimensional data outputs.
Bespoke Experimental Solutions
Providing fully customized assay development services with optimized experimental designs to address unique research objectives and challenging scientific questions.
Stringent Quality Management
Implementing internationally recognized standardized operating procedures (SOPs) complemented by multi-level quality control measures to ensure data reproducibility and reliability.
Expedited Project Execution
Employing streamlined, parallel processing workflows supported by automated systems to guarantee efficient project progression and adherence to critical timelines.
FAQ
1. What cell types do you offer for screening?
We provide a wide range of adherent and suspension cells, including cancer lines, primary human cells (e.g., PBMCs, hepatocytes), iPSCs, drug screening models (such as those for enzymology, nuclear receptors, and GPCR targets) and 3D organoids. Custom models can also be developed upon request.
2. Are large-scale high-throughput screens supported?
Yes. Our platforms are equipped for both small-scale pilot studies and large-scale HTS campaigns.
3. Do you provide raw data or just the processed results?
Both! Clients receive both processed data sets with statistical analysis and raw data files for their own re-analysis if needed.
4. Can you screen client compound libraries or cell lines?
Yes. We can conduct screening with compound libraries and/or cell lines provided by the client. We can also help with QC and preparation of the libraries/cell lines, if necessary.
5. Do you offer multiplex or multi-parameter screening services?
Yes. We have the ability to use multiparameter assays, such as combining cell viability with toxicity and differentiation markers. This allows for the collection of more than one type of data on a multi-faceted mechanism.
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