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Creative Bioarray provides high quality drug-drug interaction services to meet FDA and EMA guidance, including identification of drug metabolizing enzymes, CYP and UGT inhibition assays, and inhibition studies towards less common metabolizing enzymes, such as MAO, FMO, NAT, AOX, and CES.
Metabolism-mediated drug-drug interactions (DDI) refer to the interference of simultaneously administered drugs with each other's ADME (absorption, distribution, metabolism, and elimination) process by inducing or inhibiting the activities of drug metabolizing enzymes and/or drug transporters. Concomitant medications may result in an abrupt alteration in metabolism or transport that can lead to an unwanted augmentation or decrease in the blood level of a drug administered to a patient, changing the known safety and efficacy of a drug and leading to severe side effects. Thus evaluation of new drug candidates for DDI is recommended by the US Food and Drug Administration (FDA)1.
Figure 1. CYP3A induction2
The study of DDI for a new drug usually starts with in vitro studies to determine whether a drug is a substrate, inhibitor, or inducer of metabolizing enzymes. The assays can be carried out either at sub-cellular level or at cellular level.
Creative Bioarray provides a range of high quality in vitro DDI assessment services, including:
Creative Bioarray is dedicated to providing fast and integrated services of the highest quality to accelerate drug discovery process. With years of experience and deep knowledge in drug development, our scientific team is ready to serve you with flexible assays and tests. If you have any special needs or questions regarding our services, please feel free to contact us at email@example.com or 1-631-626-9181 to get support from our experienced experts. We look forward to working with you in the future.
Cell-Based Drug Discovery:
Drug Toxicity Services: