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  4. Cardio-Renal-Metabolic (CKM) Syndrome Model

Cardio-Renal-Metabolic (CKM) Syndrome Model

Cardio-Renal-Metabolic (CKM) syndrome is a complex, multisystem disorder characterized by the interplay between metabolic risk factors (obesity, type 2 diabetes), chronic kidney disease, and cardiovascular dysfunction. This syndrome leads to progressive multi-organ impairment, including left ventricular hypertrophy, heart failure, and renal fibrosis, and is associated with elevated cardiovascular morbidity and mortality. The prevalence of CKM-related comorbidities is estimated at 25-30% globally, reflecting the significant clinical burden and the need for effective therapeutic strategies.

Creative Bioarray's CKM ZSF1 rat model faithfully recapitulates the key pathological features of human CKM syndrome. Derived from the hybridization of obese ZDF females and SHHF males, the model exhibits spontaneous obesity, hyperglycemia, hypertension, dyslipidemia, and insulin resistance, followed by progressive cardiac and renal dysfunction. This platform enables comprehensive preclinical evaluation of drug candidates targeting cardiovascular, renal, and metabolic pathways, providing reliable endpoints for functional, histological, biochemical, and molecular analyses to support translational drug discovery.

Fig.1: Progression of CKM syndrome showing metabolic, cardiac, and renal dysfunction stages.

Fig.1: Stages of CKM syndrome (Ndumele et al., 2023)

Our Cardio-Renal-Metabolic (CKM) Syndrome Model

Animal Species

ZSF1 Rat

Modeling Method

  • Spontaneous CKM Model (ZSF1 Rat)
  • Angiotensin II-Accelerated CKM Model (ZSF1 + Ang II)

Endpoints

  • Metabolic/Body weight
    • Body weight, Blood glucose
    • Serum lipids: TG, TC LDL, HDL
  • Blood Pressure
    • Systolic (SBP) and diastolic (DBP) blood pressure
  • Renal Function
    • Urine albumin, creatinine, albumin-to-creatinine ratio (ACR)
  • Cardiac Function
    • Echocardiography
    • Heart weight
  • Histological Analysis
    • H&E, Masson's trichrome staining
  • Customized Endpoints

Key Features

  • Highly Translational

Mirrors human CKM syndrome metabolic, cardiac, and renal pathophysiology.

  • Comprehensive Endpoints

Supports functional, histological, biochemical, and molecular evaluations

  • Reliable and Reproducible

Standardized model and protocols ensure consistent results across studies.

Quotation and Ordering

Interested in leveraging Creative Bioarray's CKM ZSF1 rat model for your preclinical drug discovery or mechanistic studies? Please contact our team directly to discuss your project requirements, or submit an inquiry online to receive a customized quotation.

Reference

  1. Ndumele, C.E., et al. Cardiovascular-kidney-metabolic health: a presidential advisory from the American Heart Association. Circulation, 2023, 148(20): 1606-1635.

For research use only. Not for any other purpose.

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