Senna Extract and Neonatal Maternal Separation-Induced Irritable Bowel Syndrome (IBS) Model
If you are looking for a reliable and experienced partner to conduct preclinical research on irritable bowel syndrome (IBS), Creative Bioarray is the perfect choice. We have a proven track record of success as a full-service CRO, and our expertise in IBS research allows us to adapt to the unique needs of each trial. We can provide you with senna extract and neonatal maternal separation-induced IBS model to ensure that you get accurate and reliable results. With our commitment to quality and safety, you can trust us to provide you with the support you need to advance your research.
It has been widely accepted that early life negative events, such as loss of family member, could have detrimental impacts on individuals. This personal injury can last for a long time up to adulthood and may be a significant predictor of psychiatric disorders in adulthood. Based on this the NMS model is constructed to mimick the early deprivation of maternal care in human beings. NMS can induce visceral hypersensitivity and changes of HPA-axis. Many evidence suggests that the alteration of gut sensitivity, microbiota and immune function in NMS model is similar to that in IBS patient.
Our Senna Extract and Neonatal Maternal Separation-Induced Irritable Bowel Syndrome (IBS) Model
- Available Animal
Rat - Modeling Method
Step 1: The two-day-old newborn SD rats are separated from the mother rats for 3 hours every day for 20 days and then reared normally until they are weaned and separated from the mother rats.
Step 2: Since the 30th day, the rats are gavaged with senna extract once a day. - Group Setting (Adjustable upon your request)
Control group
Model group
Three dose groups of test compounds - Endpoints
- H&E staining: colon
- Body weight
- Fecal count
- Fecal water content
- AWR score
- Behavioral tests: open field test
- Other customized endpoints: available upon request.
Example Data
Fig. 1 Comparison of abdominal withdrawal reflex (AWR) scores between irritable bowel syndrome with diarrhea (IBS-D) rats and normal rats under different pressures.
Fig. 2 Histogram of the fecal water content in each group
Additionally, we also provide another irritable bowel syndrome (IBS) model that may be you are interested in:
Quotation and Ordering
Creative Bioarray is dedicated to providing the most suitable disease model for our clients. If you don't see the model you need, our skilled team has experience quickly reproducing models from the literature. Contact us now, to know how can we help you accelerate your drug development process.
Reference
- Wang, Y., et al. Huosha Oral Solution improves symptoms of irritable bowel syndrome with diarrhea by inhibiting activation of ERK signaling pathway and apoptosis of interstitial cells of Cajal in rats. Int J Clin Exp Med, 2019, 12(7): 8161-8171.
