Circulating Tumor Cell (CTC) FISH
Circulating tumor cells (CTCs) are rare cancer cells released from tumors into the bloodstream that are thought to have a key role in cancer metastasis. The presence of CTCs has been associated with worse prognosis in several major cancer types, including breast, prostate and colorectal cancer. There is considerable interest in CTC research and technologies for their potential use as cancer biomarkers that may enhance cancer diagnosis and prognosis, facilitate drug development, and improve the treatment of cancer patients.
Chaffer CL, et al. Science. 2011. 331(6024): 1559-64
Creative Bioarray now offers a full line of circulating tumor cell Fluorescence in situ Hybridization (FISH) services, from enrichment of CTCs, standardized testing of validated assays and custom development of new assays. The first available CTC FISH test is for HER-2 gene application. Drawing on many years of experience and in-depth knowledge in FISH, we introduce the CTC FISH services using our self-developed method to our customers.
Creative Bioarray's CTCs FISH services includes:
- Sample Preparation
We have established proprietary protocols for sample preparation that enhance efficiency of CTC enrichment, sensitivity and signal for FISH applications.
- CTC Enrichment
We have developed an effective method to enrich CTCs by negative selection, which can largely reduce the non-CTCs background and increase the percentage of CTCs in the prepared sample.
- Probe Design, Labeling and Purification
Superior sensitivity and specificity probes are designed using proprietary algorithms developed by our experts and are available with a wide selection of labels.
We rely on our wealth of development SOPs to optimize FISH hybridization conditions for each custom assay.
We deliver publication-ready data and figures to you.
Before doing each project, our scientists will discuss with you the details of the experiment design, and make recommendations to help you get the best results in the most cost-effective and fastest way.
If you have any special needs in detecting and locating specific targets in CTCs by FISH, please contact us for this special service. Let us know what you need and we will accommodate you. We look forward to working with you in the future.
For research use only. Not for any other purpose.