USA USA: 1-631-626-9181 Europe Europe: 44-207-097-1828  
Search

Tissue samples, tissue arrays, cells, microorganisms, probes and services for your research.

Web Search    Google
Featured Services
Ordering Information

Payment methods we support:
✭ Invoice / Purchase Order
✭ Credit card


In vitro Full Thickness Skin Model

Inquiry

Compared to animal ex­periments or the use of ex vivo skin, in vitro 3D Full Thickness Skin Model (Human Skin Equivalent, FTSK, HSE) used under defined test conditions of­fer several advantages: i) since most models are composed of primary human cells, inter-species extrapolation is avoided; ii) in contrast to ex vivo human skin, repeated application of formulations can be performed for at least several weeks; iii) work with the ready to use epidermal FTSK (HSE) does not require advanced knowledge of cell culture techniques; iv) the employment of FTSK (HSE) leads to the reduction of laboratory animal use in regulatory toxicology as well as in preclinical studies.

Creative Bioarray provides in vitro Full Thickness Skin Model (Human Skin Equivalent, FTSK, HSE) to our customers for developing innovative skin care products, and to cosmetic scientists for evaluating novel ingredients and formulations.

Creative Bioarray Reconstructed FTSK (HSE) are composed of a dermal compartment containing human skin fibroblasts embedded in a collagen matrix and human keratinocytes seeded on top to form the epidermis.

Creative Bioarray Full Thickness Skin Model Feature

  • The skin model closest to clinical testing
  • Large donor inventory with matched keratinocytes and fibroblasts
  • Delivered ready-to-use

In vitro Full Thickness Skin Model Fig.1 Histological examination of FTSK(HSE) model

Specific Markers

  • Filaggrin
  • Involucrin
  • Loricrin
  • Corneodesmosin
  • Procollagne1
  • Tropoelastin
  • Decorin
  • Perlecan
  • Keratin 10
  • Keratin 5
  • Presence of different epidermal classes of lipids comprising ceramides
  • collagen
  • Laminin V
  • Alpha6Beta4-integrin
  • BP antigen
  • Ki67
  • Others
In vitro Full Thickness Skin Model Fig2. Fluorescence-labeling of different markers in FTSK.
In vitro Full Thickness Skin Model Fig3. Immunol-labeling of different markers in FTSK

Applications

Creative BioarrayFTSK (HSE) can be utilized for the evaluation of toxicity and efficacy of skin therapeutics and cosmetics.

Quote and ordering

Call us today at 631-626-9181, or email us at for a technical supports or quotation! Our customer service representatives are available 24hr a day!

Related models

In vitro Reconstructed Human Epidermis (RHE)
Ex vivo Skin Explants
Neurodermatology Skin Model
Pigmented Epidermis Model
Psoriasis Skin Model


Related Sections

Skin:

In vitro Skin Models:

Customer Support & Price Inquiry
Please input "bioarray" as verification code.
CONTACT US USA
45-1 Ramsey Road, Shirley, NY 11967, USA
Tel: 1-631-626-9181
Fax: 1-631-614-7828
Email: 

Europe
Tel: 44-207-097-1828
Email: