Animal Models of Hypertension
Hypertension is identified traditionally as persistent high blood pressure (BP) and is involved in dietary, genetic and environmental factors (or more likely a combination of the three). Persistent hypertension may cause structural and functional changes in the heart, such as cardiac remodeling, myocardial systolic dysfunction and heart failure. It mainly include essential hypertension and secondary hypertension.
At present, hypertension is the most common reversible risk factor for cardio-cerebrovascular diseases. For example, about 70% of cardiovascular mortalities is associated with hypertension. Hypertension is currently a growing public health problem worldwide. However, the exact mechanism of hypertension leading to cardiovascular disease remains unclear.
Creative Bioarray focuses on drug research and development services and helps customers evaluate the drug efficacy and study the associated pathological mechanisms of hypertension by associated models.
Animal models of hypertension include but not limited to:
- Primary Hypertension Model
- Spontaneously Hypertenswe Rat Model (SHR)
- Secondary Hypertension Model
- DOCA-Salt Model
- Two-kidney-one-clip (2K1C) Renovascular Hypertension Model
Species available
- Rat
- Mouse
Our Capabilities
- We screen novel test compounds targeting hypertensive.
- Blood pressure (BP) was monitored by tail-cuff.
Assays available
- PK/PD collection
- Pathological evaluation
- Cytokine analysis
- ECG
- Blood pressure monitoring
With extensive experience in the field of hypertensive, we are confident to help you to overcome any upcoming challenges. Our experts are fully capable of customizing our protocols and assays to meet your specific needs. With our help, we wish to facilitate your research with high efficiency.
Study examples
Figure. 1. Effects of HXQY decoction on Ang II concentrations in plasma and myocardial samples of obese SHRs. (A and B) Experimental procedures were the same as in Fig. 1. After 8 weeks of treatment of SHRs, the concentrations of Ang II in peripheral blood (A) and left ventricular myocardium (B) were determined by ELISA. n = 9 for each group; ※P < 0.05, compared with the control SHR group; #P < 0.05, compared with the Obese SHR group.
Quotation and ordering
If you have any special needs or questions regarding our services, please feel free to contact us. We look forward to cooperating with you in the future.
Reference
- Stujanna E N, et al. Rev-erb agonist improves adverse cardiac remodeling and survival in myocardial infarction through an anti-inflammatory mechanism[J]. PLoS ONE, 2017, 12(12):e0189330.
