Spleen Cells

The spleen is the largest secondary lymphoid organ and plays essential roles in immune surveillance, hematological homeostasis, antigen presentation, and immune cell activation. As a key interface between the circulatory and immune systems, splenic tissues contain specialized stromal, endothelial, epithelial, and immune cell populations that regulate both innate and adaptive immune responses.

Our spleen cell portfolio includes primary human splenocytes, fibroblasts, endothelial cells, microvascular endothelial cells, and epithelial cells derived from human spleen tissue. These physiologically relevant cell models support research in immunology, inflammation, hematological disorders, immune-oncology, host-pathogen interactions, and lymphoid tissue biology.

Product List

Our Spleen Cell Portfolio Highlights

Comprehensive Spleen Cell Resources

Our collection represents major cellular components of the splenic microenvironment involved in immune regulation and tissue homeostasis.

Immune Cell Populations
- Primary human splenocytes
- Mixed immune cell populations from spleen tissue
- Models supporting immune function studies
Vascular Cell Models
- Splenic endothelial cells
- Splenic microvascular endothelial cells
- Cells for vascular and immune interaction studies
Stromal and Structural Cells
- Splenic fibroblasts
- Splenic epithelial cells
- Cells supporting tissue architecture research

Applications in Immunology and Hematology Research

Spleen-derived cells provide valuable tools for studying immune responses, lymphoid tissue biology, and immune-related diseases.

Immune Response Research

Investigate immune cell activation, antigen presentation, cytokine signaling, and adaptive immune mechanisms.
Inflammation & Autoimmune Disease Studies

Support studies of inflammatory pathways, immune dysregulation, and autoimmune disease mechanisms.
Immuno-Oncology Research

Evaluate tumor-immune interactions, immune cell functions, and novel immunotherapeutic strategies.
Host-Pathogen Interaction Studies

Explore immune responses to infectious agents and mechanisms of pathogen recognition and clearance.

4
Major Research
Applications

100 %
Mycoplasma-Free
Tested

3
Cellular Compartments
Represented

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What are splenocytes commonly used for?

Splenocytes contain diverse immune cell populations, including T cells, B cells, macrophages, dendritic cells, and NK cells, making them widely used for immune function, cytokine production, and cell activation studies.

How do splenocytes differ from PBMCs?

Compared with peripheral blood mononuclear cells, splenocytes contain a broader representation of tissue-resident immune populations and provide additional insights into lymphoid organ-specific immune responses.

Why are splenic endothelial cells important in immunology research?

Splenic endothelial cells contribute to immune cell trafficking, vascular regulation, and antigen exposure within the spleen, making them valuable for studying immune-vascular interactions.

Can spleen-derived cells be used in immuno-oncology studies?

Yes. Splenic immune cells and stromal components are frequently used to evaluate immune activation, tumor immunity, immune checkpoint pathways, and responses to immunotherapeutic agents.

What role do splenic fibroblasts play in research?

Splenic fibroblasts contribute to extracellular matrix organization and lymphoid tissue architecture and are increasingly studied for their roles in immune microenvironment regulation.

Are spleen cells suitable for host-pathogen interaction studies?

Yes. Because the spleen is a central immune organ involved in pathogen recognition and immune defense, spleen-derived cells are frequently used to investigate infectious diseases and immune responses to microbial challenges.

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