Urology Disease Models
Urology Diseases are common clinical conditions that have irreversible long-term consequences such as kidney failure, and interfere with kidney maturation. These diseases affect people of all ages, and may result in substantial disability and impaired quality of life. Acute kidney injury and chronic kidney injury are two common types among these urology diseases.
Acute kidney injury (AKI) refers to kidney failure or kidney damage that occurs suddenly in a short period of time. AKI make it difficult for the kidneys to maintain balance of fluid in the body. It can also affect other organs, such as brain, heart, and lungs. Chronic kidney disease means lasting damage to the kidneys and getting worse over time. If the kidney eventually deteriorates to failure, the patient will need regular dialysis or a kidney transplant to survive.
At Creative Bioarray, we have successfully developed 3 urology disease models to help with drug development. The application of urology animal models helps increase our understanding of urology diseases and provides new approaches to improve the diagnosis and treatment of kidney injury.
Our portfolio of urology disease models covers the following diseases
- Acute kidney injury
Unilateral ureteral obstruction model
Cisplatin-induced nephrotoxicity model
- Chronic kidney injury
5/6 Nephrectomy model
Data & Figures
Figure 1. Histology changes of obstructed kidneys at (A) 0 day, (B) 2 days, (C) 4 days, and (D) 6 days
Quotation and ordering
We have extensive experience in developing disease models based on scientific publications. To discuss any of these models further or to discuss the possibility of developing alternative models, please do not hesitate to contact us.
Martínez-Klimova. et al. Unilateral Ureteral Obstruction as a Model to Investigate Fibrosis-Attenuating Treatments. Biomolecules. 9, (2019).
For research use only. Not for any other purpose.