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Diabetes mellitus has become one of the broad endocrine diseases that threaten human health worldwide. Type 2 Diabetes Mellitus (T2DM) is the most common form of diabetes and is characterized by insulin resistance. It accounts for 90-95 % of all cases. And the development of T2DM is related to obesity, lack of physical exercise, aging and genetic predisposition. At present, the rodent is considered as a reliable model for discovering and validating new treatments for type 2 diabetes mellitus due to its small size, short generation time, etc.
Creative Bioarray specializes in providing customized pharmacodynamic research services to help customers assess the efficacy of drug candidates and study the associated pathological mechanisms through T2DM model.
Type 2 diabetes animal models include but not limited to:
With extensive experience in the field of T2MD, we are confident to help you overcome any upcoming challenges. Our experts are fully capable of customizing our protocols and assays to meet your specific needs. With our help, we wish to facilitate your research with high efficiency.
Figure. 1. T2DM-induced increase of the blood plasma levels of glucose (mmol/l, 48 h after STZ)
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Pechlivanova, Daniela, et al. "Protective effects of losartan on some type 2 diabetes mellitus-induced complications in Wistar and spontaneously hypertensive rats." Metabolic Brain Disease (2020): 1-12.
Metabolic Disease Models: