HLA-Typed Cells
Creative Bioarray maintains a large, ethnically diverse donor pool of HLA-typed primary cells. Every batch ship with a complete 4-digit resolution HLA typing certificate covering Class I (HLA-A, -B, -C) and Class II (HLA-DRB1/DRB345, -DQA1/DQB1, -DPA1/DPB1) — so you can eliminate screening bottlenecks and focus on science.
- 200+ HLA-typed donors in stock and ready to ship
- Matched sets from the same donor (PBMCs + subsets + fibroblasts)
- High-resolution (4-digit) protein-level HLA typing as standard
- Full anonymized donor metadata (age, sex, ethnicity, BMI)
- Ethical sourcing with full informed consent and IRB oversight
Why Choose Our HLA-Typed Cells?
Verified High-Resolution HLA Typing
Every batch is typed at 4-digit resolution (protein level) for HLA-A, -B, -C (Class I) and HLA-DRB1/DRB345, -DQA1/DQB1, -DPA1/DPB1 (Class II) using sequence-based typing or NGS methods.
Stringent Sterility & Viability QC
Beyond HLA, cells are tested for viability (Trypan blue / flow cytometry), sterility (bacteria, fungi), and mycoplasma contamination. Post-thaw viability is guaranteed ≥90% for cryopreserved products.
Functional Validation Where It Matters
Optional functional QC includes antigen-presentation capability (T-cell activation assays), cytokine response profiles (IFN-γ, IL-2, TNF-α), and mixed lymphocyte reaction (MLR) confirmation — so you know the cells work before you start.
Full Traceability & Ethical Compliance
All primary cells are obtained from fully consented donors under IRB-approved protocols. We provide detailed, anonymized donor metadata (age, sex, ethnicity, BMI, smoking status) and a complete chain-of-custody record.
Key Applications of Our HLA-Typed Cells
Vaccine Immunogenicity
Evaluate vaccine-induced T-cell responses across different HLA backgrounds to predict population-level efficacy.
Cell Therapy Development
Assess TCR-T and CAR-T functionality against HLA-matched target cells with physiologically relevant precision.
Immunotoxicity Screening
Predict drug-induced immune reactions in preclinical models with authentic HLA context.
Transplantation Research
Model alloreactivity, study GvHD mechanisms, and develop donor-recipient matching strategies.
Autoimmune Disease
Explore disease mechanisms linked to specific alleles (e.g., HLA-DRB1*04:01 in Type I diabetes).
Precision Medicine
Generate robust, publication-quality data with high biological fidelity for translational studies.
Custom HLA Donor Screening & Cell Engineering
Need a rare allele or a specific haplotype combination? Our custom services include:
- Custom donor recruitment for target HLA alleles, including homozygous donors.
- HLA-engineered cell line generation (single-allele K562, CHO, or HLA-null base lines).
- EBV transformation to generate B-LCLs from your donor PBMCs.
- HLA-typed iPSC reprogramming and differentiation services.
- Custom functional validation (tetramer staining, antigen-specific T-cell expansion, MLR).
FAQ
What HLA resolution do you provide as standard?
All donors are typed at 4-digit resolution for HLA-A, -B, -C, -DRB1, -DRB3/4/5, -DQA1/DQB1, and -DPA1/DPB1 using NGS. Higher-resolution typing (6- or 8-digit) is available on request.
How many HLA-typed donors do you have in stock?
We maintain a continuously expanding inventory of 200+ pre-typed donors across Class I and Class II alleles, covering the majority of common and well-documented (CWD) alleles in major global populations.
Can I receive PBMCs and isolated T cells from the same donor?
Yes. Our matched donor sets allow you to order PBMCs, CD4+/CD8+ T cells, B cells, NK cells, monocytes, dendritic cells, and fibroblasts from one donor — essential for autologous and HLA-matched study designs.
Are your HLA-typed cells suitable for CAR-T / TCR-T off-target safety screening?
Absolutely. We supply HLA-matched and HLA-mismatched primary cells from lung, kidney, liver, cardiac, neural, and endothelial tissues — the standard substrate for cross-reactivity and on-target / off-tumor safety assessments.
Can you screen donors for a specific allele I need?
Yes — through our custom HLA donor screening service. Submit your target alleles (e.g., HLA-A*02:01, HLA-B*27:05, HLA-DRB1*04:01) and we will recruit, type, and supply matching donors.
Do you offer GMP-aligned or clinical-grade HLA-typed cells?
Standard offerings are Research Use Only (RUO). GMP-aligned material for preclinical and IND-enabling work is available upon request — please contact our team to discuss your regulatory pathway.
What is the typical turnaround time?
In-stock cryopreserved lots ship within 48 hours of order confirmation. Custom donor recruitment and HLA-engineered cell line projects are typically completed in 4–12 weeks depending on scope.
Accelerate Your Research with HLA-Typed Cells
Tell us your target alleles, cell types, and timelines — our scientific team will respond with matching in-stock donors and a quote as quickly as possible.
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