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Staffed with well-experienced experts in the field, Creative Bioarray now provides high throughput ADME (HT-ADME) package using state-of-the-art instrumentation and methodology to accelerate the lead optimization and drug discovery process, contributing to decreasing the high attrition rate at the same time.
Drug discovery is a high-risk, high-cost, but also highly rewarding business. Evaluation of drug metabolism and optimization of drug ADME properties at an early stage is of great importance in drug discovery and development. Without proper early evaluation, many resources can be invested, and thus wasted, in candidate products that are subsequently found to have unacceptable ADME profiles when evaluated in late stages. In order to avoid unnecessary lost, Creative Bioarray has established several reliable in vitro ADME models, and offers an industrialized high-throughput ADME screening and profiling service for routine compound screening.
As a robust and useful tool for early phase drug discovery, High Throughput Screening (HTS) is widely used in hit-to-lead and lead optimization process, and enables the screening of a large number of compounds in a cost and time efficient manner. Our HTS ADME assays can be modified and customized to meet the requirements of our clients using project specific study set up. With our state-of-the-art equipment, we are able to screen up to 300 compounds per week.
The ADME screening process consists of the following 5 steps:
In vitro ADME screening can generate a large quantity of data to address various ADME issues at different stages of drug discovery and development to avoid development mistakes early and de-risk the investment.
We provide HT-ADME services in the following areas:
Creative Bioarray’s HT-ADME group offers a variety of benefits:
With extensive experience in the field and state-of-the-art instrumentation, Creative Bioarray is capable of providing robust and cost-efficient HT-ADME assays with high quality and consistent data. We can also customize the assay according to the purpose of the clients. Please feel free to contact us at firstname.lastname@example.org or 1-631-626-9181 to find out more about our capabilities and services.