Colorectal Tumor Cells
Colorectal tumors, primarily arising from the epithelial lining of the colon and rectum, are among the most prevalent malignancies worldwide. These cancers develop through a well-characterized multistep process involving the accumulation of genetic alterations, leading to the transition from normal mucosa to adenoma and ultimately carcinoma.
Our colorectal tumor cell line collection provides biologically relevant in vitro models for studying tumor initiation, progression, and metastasis, as well as for evaluating therapeutic strategies and investigating mechanisms of drug resistance in colorectal cancer.
Reliable Authentic Diverse Supported
Key Features & Expertise
Our colorectal tumor cell lines support a wide range of translational and mechanistic studies
Models Covering Tumor Progression Spectrum
- Includes cell lines derived from primary tumors and metastatic lesions
- Represents different stages of colorectal cancer development
- Suitable for studies on tumor progression, invasion, and metastasis
Well-Defined Genetic and Molecular Background
- Frequent mutations in key genes such as APC, KRAS, and TP53
- Representation of major signaling pathways including Wnt/β-catenin and MAPK
- Applicable to studies of tumorigenesis and targeted therapy response
Reliable Models for Drug Discovery
- Widely used models such as HCT116, HT-29, and SW480
- Suitable for high-throughput screening and pharmacological studies
- Enable investigation of chemotherapy response and resistance mechanisms
FAQ
What types of colorectal tumor cell lines are included?
The collection includes a variety of colorectal cancer cell lines derived from both primary tumors and metastatic sites, covering different stages and biological characteristics of the disease.
What are the key genetic features of colorectal cancer models?
Colorectal cancer commonly involves mutations in genes such as APC, KRAS, and TP53, which drive tumor initiation and progression through pathways like Wnt/β-catenin and MAPK signaling.
How do I choose the right colorectal cancer cell line?
Selection depends on your research focus. Key considerations include:
- Mutation profile ( e.g. , KRAS, BRAF, or TP53 status)
- Origin (primary vs. metastatic tumor)
- Drug sensitivity and resistance characteristics
- Suitability for 2D, 3D, or organoid-based systems
Can these models be used to study tumor progression?
Yes, colorectal cancer follows a well-defined progression model involving sequential genetic alterations, making these cell lines particularly useful for studying tumor development and evolution.
Are colorectal tumor cell lines suitable for drug screening?
Yes, these models are widely used in drug discovery and screening, enabling evaluation of chemotherapeutics, targeted therapies, and combination treatment strategies in colorectal cancer.
Do these models reflect molecular heterogeneity?
While individual cell lines represent specific genetic backgrounds, using a panel of colorectal cancer models allows researchers to capture the molecular diversity of the disease, including variations in key oncogenic pathways.
How should colorectal tumor cell lines be stored and handled?
Cell lines are typically supplied as cryopreserved vials or shipped on dry ice. Upon receipt, they should be stored in liquid nitrogen and maintained using standard cell culture practices to ensure optimal performance.
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Description: The Adriamycin-resistant cell line HCT8/ADR has been developed by repeatedly exposing the parent ...
Description: The Fluorouracil-resistant cell line HCT8/5FU has been developed by repeatedly exposing the parent ...
Description: The Oxaliplatin-resistant cell line HCT8/L-OHP has been developed by repeatedly exposing the parent ...
Description: The Paclitaxel-resistant cell line HCT-15/taxol has been developed by repeatedly exposing the ...
Description: Species: human, Caucasian male 53 years old; Tissue: rectum; Tumor: adenocarcinoma, grade IV
Description: Established from the ascites fluid of a 71-year-old man with colon carcinoma in 1975; The cell line ...
Description: Established from the tumor mass of a 55-year-old Caucasian woman with a moderately undifferentiated ...
Description: Established from a colorectal adenocarcinoma; HCT-15 is a sister cell line of the cell line DLD-1. ...
Description: The Fluorouracil-resistant cell line HCT-15/5FU has been developed by repeatedly exposing the ...
Description: The Paclitaxel-resistant cell line HCT-8/taxol has been developed by repeatedly exposing the parent ...
Description: Established from the primary tumor at the left colon (a moderately differentiated colorectal ...
Description: Established from a male patient with a well-differentiated primary sigmoid adenocarcinoma of TNM ...
Description: Established from a woman with a moderately differentiated primary adenocarcinoma of the right colon ...
Description: Established from the primary colorectal cancer (TNM stage 3) of the right colon of a woman; cells ...
Description: Established from the primary colon carcinoma of an adult man; cells were described to carry a RAS ...
Description: The Cisplatin-resistant cell line HCT-116/DDP has been developed by repeatedly exposing the parent ...
Description: The Onvansertib-resistant cell line HCT-116/Onv has been developed by repeatedly exposing the ...
Description: Subline of H414 cell line lacking MDC1 gene in both alleles.