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Skin corrosion refers to the production of irreversible damage to the skin manifested as visible necrosis through the epidermis and into the dermis, following the application of a test chemical. The potential for chemical induced skin corrosion is an important consideration in establishing procedures for the safe handling, packing and transport of chemicals. As an alternative to the animal-based Skin Corrosion Test, Skin Corrosion potential can be predicted by in vitro systems, provided they are sufficiently complex to mimic skin barrier in vivo and cell reactivity.
Creative Bioarray provides in vitro systems for skin corrosion assays including skin models and in vitro testing services to our customer utilized by the cosmetics, personal care, household products, chemical, pharmaceutical, and biotech industries.
Creative Bioarray's skin corrosion test is preformed using our or the customer's Reconstructed human epidermis (RHE) based on the OECD Test guidelines 431. Creative Bioarray follows the standardised skin corrosion test procedure within the OECD guidelines.
Fig 1. Corrosion rate after treatment of RHE model with different compounds.
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In vitro Skin Models: