Pancreatic Cells
The pancreas is a highly specialized organ responsible for both endocrine and exocrine functions. Pancreatic islets regulate glucose metabolism through hormone secretion, while epithelial, stromal, and vascular cell populations coordinate tissue homeostasis, extracellular matrix remodeling, and local signaling. Alterations in these cellular networks are closely associated with diabetes, chronic pancreatitis, pancreatic fibrosis, and pancreatic cancer.
Our pancreatic cell portfolio includes primary human pancreatic islets, epithelial cells, stellate cells, fibroblasts, stromal cells, and microvascular endothelial cells. These physiologically relevant models support research in pancreatic biology, metabolic disorders, fibrosis, tumor microenvironment interactions, angiogenesis, and regenerative medicine.
4
Major Pancreatic
Cell Compartments
100 %
Mycoplasma-Free
Tested
24-72 h
Rapid
Delivery
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Our Pancreatic Cell Portfolio Highlights
Comprehensive Pancreatic Cell Resources
Our collection captures the major functional and structural components of pancreatic tissue.
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Endocrine Cell Models
- Primary human pancreatic islets
- Models for insulin secretion and glucose-response studies
- Suitable for diabetes and metabolic disease research
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Stromal and Fibrotic Cell Models
- Pancreatic stellate cells (PSC)
- Pancreatic fibroblasts and stromal cells
- Pancreatic cancer-associated fibroblasts (CAF)
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Epithelial and Vascular Components
- Pancreatic epithelial cells
- Pancreatic microvascular endothelial cells
- Fluorescent endothelial cell models for imaging applications
Applications in Pancreatic Disease Research
These cell models enable mechanistic studies across metabolic disorders, fibrotic diseases, and pancreatic malignancies.
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Diabetes and Islet Function Studies
Evaluate insulin secretion, glucose responsiveness, islet viability, β-cell biology, and diabetes-associated dysfunction.
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Pancreatic Fibrosis Research
Investigate stellate cell activation, extracellular matrix deposition, tissue remodeling, and chronic pancreatitis-related fibrosis.
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Pancreatic Cancer Microenvironment Modeling
Examine interactions among tumor cells, stromal cells, fibroblasts, and endothelial cells within desmoplastic pancreatic tumors.
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Angiogenesis and Regenerative Biology
Support studies of vascular remodeling, endothelial signaling, tissue repair, and pancreatic regeneration.
Why are pancreatic stellate cells widely used in fibrosis research?
Pancreatic stellate cells are the principal mediators of extracellular matrix production in the pancreas. Upon activation, they contribute to fibrogenesis, tissue remodeling, and chronic pancreatitis-associated fibrosis.
How can pancreatic islets support diabetes research?
Primary human pancreatic islets provide a physiologically relevant system for evaluating insulin secretion, glucose-stimulated responses, islet survival, and mechanisms underlying diabetes progression.
What makes pancreatic cancer-associated fibroblasts important for oncology studies?
Pancreatic CAFs are major components of the desmoplastic tumor microenvironment and influence tumor growth, immune regulation, extracellular matrix remodeling, and therapeutic resistance.
Can pancreatic cells be used to establish multicellular co-culture models?
Yes. Combining pancreatic epithelial cells, stromal cells, endothelial cells, and islets enables the development of more physiologically relevant in vitro systems for studying pancreatic biology and disease mechanisms.
What applications are supported by GFP-expressing pancreatic endothelial cells?
Fluorescent endothelial cell models facilitate live-cell imaging, angiogenesis assays, cell tracking studies, and visualization of vascular interactions within complex pancreatic culture systems.