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Exposure to solar UV radiation (UVA, thermal component, UVB) is the main environmental factor that causes premature aging of the skin (photo-aging). Human skin aging resulting from UV irradiation is a cumulative process that occurs based on the degree of sun exposure and the level of skin pigment. UV irradiation induces matrix metalloproteinases (MMPs) responsible for alterations in the collagenous extracellular matrix of connective tissue, resulting in impaired integrity. On a molecular level, UV radiation from the sun attacks keratinocytes and fibroblasts, resulting in the activation of cell surface receptors, which initiate signal transduction cascades. This in turn leads to a variety of molecular changes, which causes a breakdown of collagen in the extracellular matrix and a shutdown of new collagen synthesis.
In order to identify most efficient applications of the new ingredients of UV-Protection, the need for in vitro testing in cosmetic or dermatological industries is greatly growing nowadays, because of below aspects: firstly, regulatory affairs that include consumer safety and strict ban of animal use in testing. Secondly, there is a big advantage regarding research and development because of faster screening and access to more informative tests. Finally, this leads to on the evidence based communication with consumers.
Creative Bioarray provides in vitro 3D skin tissue models and evaluation assays performed for cosmetic or dermatological efficacy and claims support of photo-aging & UV protection.
In vitro 3D skin models available
Fig 1. Cosmetic ingredient inhibits UVA-induced MMP-1 release
Fig 2. Comparison of relative expression of MMP-1 and MMP-3 in UVB group and control group.
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In vitro Skin Models: