Streptozotocin Induced Diabetes Mellitus Model
Streptozotocin (STZ) is an antibiotic isolated from Streptomyces achromogenes and is commonly used to establish a model of type 1 diabetes mellitus (T1DM) due to its ability to selectively destroy pancreatic islet β cells. STZ-induced T1DM model was produced by multiple administrations of low-dose STZ in mice, which mimics human T1DM with chronic pancreatic islet inflammation, insulitis, and insulin deficiency. Also, STZ can be used in type 2 diabetes mellitus (T2DM) model by the combination of STZ and nicotinamide.
Creative Bioarray focuses on drug research and development services and helps customers assess the pathological consequences of diabetes and screen potential therapies for the treatment of this condition.
Species available
- Rat
- Mouse
Our capabilities
- We test the levels of advanced glycation end products (AGEs), MDA, GSH as well as the activities of SOD and CAT by Elisa.
Assays available
- Blood glucose levels and body weight
- Biochemical analysis
- Pathological evaluation
With extensive experience in the field of cardiac diabetes, we are confident to help you overcome any upcoming challenges. Our experts are fully capable of customizing our protocols and assays to meet your specific needs. With our help, we wish to facilitate your research with high efficiency.
Study examples
Figure. 1. Effects of Gryllus bimaculatus powder on blood glucose, plasma C-peptide, and plasma insulin levels in an STZ-induced diabetic rat model.
Figure. 2. Effects of Gryllus bimaculatus powder on glucose (glucose tolerance test; GTT) and insulin tolerance (insulin tolerance test; ITT) states
Quotation and ordering
If you have any special needs or questions regarding our services, please feel free to contact us. We look forward to cooperating with you in the future.
Reference
Park et al. "Glucose‐lowering effect of Gryllus bimaculatus powder on streptozotocin‐induced diabetes through the AKT/mTOR pathway." Food Science & Nutrition 8.1 (2020): 402-409.
