ISH/FISH Analysis for Therapeutic R&D
Therapeutic R&D increasingly requires spatially resolved molecular analysis to understand disease mechanisms, target engagement, and treatment response. In oncology and cell-based therapies, genetic alterations, transcript heterogeneity, and immune signaling within the tissue microenvironment play critical roles in therapeutic efficacy and resistance, which are often not fully captured by bulk analytical approaches.
ISH and FISH allow visualization of genes, RNA transcripts, immune mediators and engineered or transplanted cells at the cellular and tissue level. These methods provide contextual spatial information across tumor tissue, circulating tumor cells (CTCs), cell therapies and preclinical models to aid target validation, mechanism-of-action and translational decision making throughout drug development.
Featured Services
Precisely identifies gene amplification, deletion, or translocation in tumors to assess prognosis and guide companion diagnostics.
Circulating Tumor Cell (CTC) FISH
Highly sensitive cytogenetic analysis of rare circulating tumor cells to enable liquid biopsy–based studies of tumor heterogeneity and disease progression.
In Situ Detection of Chemokines/Cytokines
Spatial analysis of immune signaling molecules to evaluate local inflammatory and immune response dynamics.
In Situ Detection of CAR-T Cells & Oncolytic Viruses
Spatial localization and persistence analysis of engineered immune cells and viral vectors within tissue sections to support biodistribution and mechanism-of-action studies.
CAR-T/CAR-NK Target Assessment (ISH)
In situ evaluation of target antigen expression at the RNA level, enabling assessment of target availability, heterogeneity, and therapeutic suitability.
Mouse Model and PDX Analysis (FISH)
Chromosomal and molecular characterization of tumors in mouse and patient-derived xenograft models to support preclinical oncology and translational research.
Cell Transplantation Analysis (FISH)
Track transplanted cell survival, migration, and integration in host tissues using FISH labeling.
Why Choose US
Our FISH/ISH service allows visualization of gene and RNA expression within the tissue section, providing spatial biological context beyond traditional bulk assays.
Spatial Resolution
We have a seasoned bioinformatics team to help customize and validate FISH/ISH probes with high specificity, covering key targets and markers for oncology and cell therapy applications.
Probe Design and Validation Expertise
Our services have been successfully deployed in multiple preclinical development programs for CAR-T, oncolytic viruses, and small molecules, demonstrating a deep understanding of translational research requirements.
Translational Experience
We have the experience in processing a wide range of diverse and difficult biological samples, including FFPE tissue, fresh/frozen tissue, cell smears, and blood CTCs to accommodate your experimental needs.
Sample Handling Capabilities
Applications Across the Development Pipeline
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