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As a heterogeneous organ with many vital functions, liver plays a central role in transforming and clearing chemicals thus is susceptible to the toxicity from these agents. Liver suffers the most from drug toxicity, making drug-induced liver injury (DILI) the leading cause of drug failures. Hepatotoxicity implies chemical-driven liver damage. It can be induced by a drug itself or indirectly by the generation of reactive metabolites.
Fig.1 Molecular events leading to drug-induced liver cell damage and death
The etiology of drug induced liver disease is still under debate but is generally regarded as a continuum between an activated immune response and hepatocyte metabolic dysfunction most often resulting from an intermediate reactive metabolite. In vitro cell-based toxicity assays could mimic in vivo tissue studies and in turn provide a reliable tool for safety evaluation in early stages of drug discovery.
Creative Bioarray provides a series of in vitro models and assays to help researchers assess drug hepatotoxicity potential in preclinical stage.
Creative Bioarray has developed a multiplexed hepatotoxicity assays using various in vitro hepatology models, such as primary hepatocytes, HepG2 cell lines and 3D hepatic models to predict DILI. These multi-endpoint analyses provide a thorough assessment of hepatotoxicity while supplying detailed mechanistic information underlying the observed toxicity. Our experienced scientists will assist you with meeting your objectives and support your projects.
- Creative Bioarray has established various hepatotoxicity assays using 2D-cultures of hepatocytes, which will be evaluated by several items such as cell viability, apoptosis, cellular stress, cytoplasmic membrane disruption and mitochondrial membrane potential.
- Creative Bioarray offers hepatotoxicity screening service using 3D cell culture models derived from hepatocytes of several different species. As a world-class supplier of 3D cell culture models, and with extensive experience in drug discovery through years of practice, Creative Bioarray is able to provide you with highly reliable data on drug hepatotoxicity.
If you have any needs or questions, please contact us at email@example.com or 1-631-626-9181. Our customer service representatives are available 24hr a day! We thank you for choosing Creative Bioarray services!