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In vitro Reconstructed Human Epidermis (RHE)


In vitro 3D reconstructed human epidermis from normal human keratinocytes cultured on an inert polycarbonate filter at the air-liquid interface, in a chemically defined medium. This model exists at different stages of maturity. The Creative Bioarray Reconstructed Human Epidermis Model (RHE) is very similar to human skin in terms of morphology, of differentiation markers and of functional characteristics.

In vitro Reconstructed Human Epidermis (RHE) Fig.1 Representative histology for 3D culture raised to air-liquid interface, structures are histologically similar to in vivo human epidermis.

Specific Markers

  • Filaggrin
  • Involucrin
  • Loricrin
  • corneodesmosin
  • Keratin 10
  • Keratin 5
  • Presence of different epidermal classes of lipids comprising ceramides
  • Type IV collagen
  • Laminin V
  • Alpha6Beta4-integrin
  • BP antigen
  • Ki67
  • Others

In vitro Reconstructed Human Epidermis (RHE) Fig.2 Epidermal differentiation and dermal matrix markers by Native Skin and in vitro RHE model


Creative Bioarray Reconstructed Human Epidermis Model (RHE) is cultured at the air-liquid interface and allows for the evaluation of topically applied compounds, chemicals, cosmetic/personal care product ingredients and final formulations.

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Call us today at 631-626-9181, or email us at for a technical supports or quotation! Our customer service representatives are available 24hr a day! We thank you for choosing Creative Bioarray services!

Related models

In vitro Full Thickness Skin Model
Ex vivo Skin Explants
Neurodermatology Skin Model
Pigmented Epidermis Model
Psoriasis Skin Model

Related Sections


In vitro Skin Models:

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45-1 Ramsey Road, Shirley, NY 11967, USA
Tel: 1-631-626-9181
Fax: 1-631-614-7828

Tel: 44-207-097-1828