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- Stem Cell Research
- iPSC Characterization
Services
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Cell Services
- Cell Line Authentication
- Cell Surface Marker Validation Service
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Cell Line Testing and Assays
- Toxicology Assay
- Drug-Resistant Cell Models
- Cell Viability Assays
- Cell Proliferation Assays
- Cell Migration Assays
- Soft Agar Colony Formation Assay Service
- SRB Assay
- Cell Apoptosis Assays
- Cell Cycle Assays
- Cell Angiogenesis Assays
- DNA/RNA Extraction
- Custom Cell & Tissue Lysate Service
- Cellular Phosphorylation Assays
- Stability Testing
- Sterility Testing
- Endotoxin Detection and Removal
- Phagocytosis Assays
- Cell-Based Screening and Profiling Services
- 3D-Based Services
- Custom Cell Services
- Cell-based LNP Evaluation
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Stem Cell Research
- iPSC Generation
- iPSC Characterization
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iPSC Differentiation
- Neural Stem Cells Differentiation Service from iPSC
- Astrocyte Differentiation Service from iPSC
- Retinal Pigment Epithelium (RPE) Differentiation Service from iPSC
- Cardiomyocyte Differentiation Service from iPSC
- T Cell, NK Cell Differentiation Service from iPSC
- Hepatocyte Differentiation Service from iPSC
- Beta Cell Differentiation Service from iPSC
- Brain Organoid Differentiation Service from iPSC
- Cardiac Organoid Differentiation Service from iPSC
- Kidney Organoid Differentiation Service from iPSC
- GABAnergic Neuron Differentiation Service from iPSC
- Undifferentiated iPSC Detection
- iPSC Gene Editing
- iPSC Expanding Service
- MSC Services
- Stem Cell Assay Development and Screening
- Cell Immortalization
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ISH/FISH Services
- In Situ Hybridization (ISH) & RNAscope Service
- Fluorescent In Situ Hybridization
- FISH Probe Design, Synthesis and Testing Service
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FISH Applications
- Multicolor FISH (M-FISH) Analysis
- Chromosome Analysis of ES and iPS Cells
- RNA FISH in Plant Service
- Mouse Model and PDX Analysis (FISH)
- Cell Transplantation Analysis (FISH)
- In Situ Detection of CAR-T Cells & Oncolytic Viruses
- CAR-T/CAR-NK Target Assessment Service (ISH)
- ImmunoFISH Analysis (FISH+IHC)
- Splice Variant Analysis (FISH)
- Telomere Length Analysis (Q-FISH)
- Telomere Length Analysis (qPCR assay)
- FISH Analysis of Microorganisms
- Neoplasms FISH Analysis
- CARD-FISH for Environmental Microorganisms (FISH)
- FISH Quality Control Services
- QuantiGene Plex Assay
- Circulating Tumor Cell (CTC) FISH
- mtRNA Analysis (FISH)
- In Situ Detection of Chemokines/Cytokines
- In Situ Detection of Virus
- Transgene Mapping (FISH)
- Transgene Mapping (Locus Amplification & Sequencing)
- Stable Cell Line Genetic Stability Testing
- Genetic Stability Testing (Locus Amplification & Sequencing + ddPCR)
- Clonality Analysis Service (FISH)
- Karyotyping (G-banded) Service
- Animal Chromosome Analysis (G-banded) Service
- I-FISH Service
- AAV Biodistribution Analysis (RNA ISH)
- Molecular Karyotyping (aCGH)
- Droplet Digital PCR (ddPCR) Service
- Digital ISH Image Quantification and Statistical Analysis
- SCE (Sister Chromatid Exchange) Analysis
- Biosample Services
- Histology Services
- Exosome Research Services
- In Vitro DMPK Services
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In Vivo DMPK Services
- Pharmacokinetic and Toxicokinetic
- PK/PD Biomarker Analysis
- Bioavailability and Bioequivalence
- Bioanalytical Package
- Metabolite Profiling and Identification
- In Vivo Toxicity Study
- Mass Balance, Excretion and Expired Air Collection
- Administration Routes and Biofluid Sampling
- Quantitative Tissue Distribution
- Target Tissue Exposure
- In Vivo Blood-Brain-Barrier Assay
- Drug Toxicity Services
iPSC Characterization
iPSC generation has become increasingly easier because of advanced technology, but the characteristics of various iPSCs is depending on the source, derivation, passage and culture conditions. In order to evaluate the pluripotency, safety and confirm the identity of PSCs, it is essential to perform a set of characterization analysis. Creative Bioarray offers comprehensive iPSC characterization services designed to ensure the quality, safety, and functionality of iPSC lines for diverse research and therapeutic applications. Leveraging advanced technologies and a rigorous quality management system, these services are critical for validating iPSC pluripotency, genomic integrity, and differentiation potential.
Creative Bioarray Offers iPSC Characterization Service as Follows (including but not limited to):
- 1. Pluripotency Validation
We offer comprehensive services for staining pluripotency and lineage-specific markers in stem cells. This includes live staining, immunocytochemistry, and gene expression analysis to accurately identify and quantify the pluripotent characteristics of stem cells.
- 2. Genomic Stability Assessment
Our karyotyping services aim to detect genetic stability in cells. Utilizing advanced chromosome analysis techniques such as comparative genomic hybridization and multicolor FISH, we can identify potential genomic abnormalities or chromosomal variations.
- 3. Differentiation Potential Testing
Understanding the differentiation potential of stem cells is crucial for regenerative medicine. Our services evaluate differentiation capabilities both in vitro and in vivo, including embryoid body and teratoma formation assays.
- 4. Quality Control and Safety
Microbiological contamination testing is vital for ensuring sterility and safety in cell cultures. We provide precise mycoplasma and other pathogen testing services to ensure a contaminant-free experimental environment.
- 5. Verification of homology
Using DNA fingerprinting, we offer validation services for the homology of starting cells to ensure consistency across cell populations, supporting high-quality experimental results.
- 6. Verification of Exogenous Gene Silencing
Our services include detecting and verifying the silencing of exogenous gene expression to ensure the efficacy and safety of transgenic applications, supporting gene therapy research.
References
- Singh U, Quintanilla R H, et al. Novel Live Alkaline Phosphatase Substrate for Identification of Pluripotent Stem Cells. Stem Cell Rev and Rep 8, 2012. 1021–1029.
- Pino-Barrio MJ, García-García E, et al. V-myc immortalizes human neural stem cells in the absence of pluripotency-associated traits. PLoS One. 2015. 10(3):e0118499.
- Riegel M. Human molecular cytogenetics: From cells to nucleotides. Genet Mol Biol. 2014. 37(1 Suppl):194-209.
- Jiang G, Di Bernardo J, et al. Induced pluripotent stem cells from human placental chorion for perinatal tissue engineering applications. Tissue Eng Part C Methods. 2014. 20(9):731-40.
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