Collagen Antibody-Induced Arthritis (CAIA) Model
Collagen Antibody-Induced Arthritis (CAIA) in mice is induced through intraperitoneal injection of a monoclonal antibody cocktail (C-Ab) and lipopolysaccharide. The occurrence of Rheumatoid arthritis in the CAIA mice is determined by parameters such as the increase in arthritis score and mechanical and thermal hyperalgesia. A key advantage of this model is that it can induce RA in many strains of mice which were known to be resilient to the traditional collagen-induced arthritis methods. In addition, the pharmacodynamics evaluation could be completed within a relatively shorter period by using CAIA model. Creative Bioarray provides you with CAIA Model to test the efficacy of novel therapeutics.
Our Capabilities
- We use CAIA Model to test the efficacy of drugs against Rheumatoid arthritis.
- We assess the severity of Rheumatoid arthritis in animals by clinical scoring system.
- We evaluate various biomarkers and cytokines through WB, IHC, ELISA, etc.
Assays available
- Clinical score
- Histopathology
- Biomarker analysis
- Cytokine analysis
- PK/PD blood analysis
- Paw volume
- Ankle thickness
With extensive experience in the field of Arthritis, we are confident to help you to overcome any upcoming challenges. Our experts are fully capable of customizing our protocols and assays to meet your specific needs. With our help, we wish to facilitate your research with high efficiency.
Study examples
Figure. 1. BCP treatment reduces the severity of Arthritis.
Figure. 2. BCP Preserves Articular Cartilage. Representative H&E and Safranin O staining of joints from mice: Sham (A,D), CAIA (B,E) and CAIA + BCP (C,F). The graph (G) represents the histological score. Data are expressed as means ± SD. ***p<0.0001 vs. Sham; ##p<0.001 vs. CAIA.
Quotation and ordering
If you have any special needs or questions regarding our services, please feel free to contact us. We look forward to cooperating with you in the future.
Reference
Natasha Irrera et al. β-Caryophyllene Mitigates Collagen Antibody Induced Arthritis (CAIA) in Mice Through a Cross-Talk between CB2 and PPAR-γ Receptors[J]. Front Pharmacol. 2019;659.
