USA USA: 1-631-626-9181 Europe Europe: 44-208-144-6005  

Search

Tissue samples, tissue arrays, cells, microorganisms, probes and services for your research.

Web Search    Google
Featured Services
Ordering Information

Payment methods we support:
✭ Invoice / Purchase Order
✭ Credit card


Inflammatory Bowel Disease Models

Inquiry

Inflammatory bowel disease (IBD) is a chronic intestinal inflammatory disorder which encompasses Crohn's disease (CD) and ulcerative colitis (UC). It is well known that genes, immune and environmental factors play a vital role in the occurrence of IBD. At present, the prevalence of IBD is over 0.3% worldwide. And about 70 different kinds of animal models have been established to research IBD so far, which are mainly divided into chemically induced model, genetically engineered model, cell-transfer colitis model and congenial mutant model.

Creative Bioarray focuses on drug research and development services and helps customers explore novel therapeutic options and understand the pathogenesis of IBD by IBD models.

ColitisFigure. 1. Colitis

Creative Bioarray provides you with inflammatory bowel disease models including but not limited to:

Our capabilities

  • We utilize Inflammatory bowel disease models to test the efficacy of drug candidates targeting IBD.
  • We assess the severity of IBD through clinical analysis including weight loss, diarrhea and occult blood in stool.
  • We evaluate various cytokines through IHC, ELISA, etc.

Assays available

  • Clinical analysis
  • Histopathological evaluation
  • Analysis of mRNA and protein levels
  • Cytokine/chemokine analysis
  • Immunohistochemistry

With extensive experience in the field of IBD, we are confident to help you to overcome any upcoming challenges. Our experts are fully capable of customizing our protocols and assays to meet your specific needs. With our help, we wish to facilitate your research with high efficiency.

Study examples

DSS-induced intestinal inflammation in mice. Eight-week-old C57BL6 mice were given 2.5% DSS in drinking water for 7 days. Control mice were given water only. On day 8, mice were sacrificed and monitored for colitis. (A) Gross picture of colons. (B) Endoscopic examination of colons. (C) H&E-stained colonic sections. Arrows indicate: (1) shortened and bleeding colons, (2) enlarged spleen, (3) superficial inflammation, (4) epithelial erosion and immune cell infiltration in DSS-treated mice.Figure. 2. DSS-induced intestinal inflammation in mice. Eight-week-old C57BL6 mice were given 2.5% DSS in drinking water for 7 days. Control mice were given water only. On day 8, mice were sacrificed and monitored for colitis. (A) Gross picture of colons. (B) Endoscopic examination of colons. (C) H&E-stained colonic sections. Arrows indicate: (1) shortened and bleeding colons, (2) enlarged spleen, (3) superficial inflammation, (4) epithelial erosion and immune cell infiltration in DSS-treated mice.

Quotation and ordering

If you have any special needs or questions regarding our services, please feel free to contact us at 631-626-9181 or . We look forward to cooperating with you in the future.

Reference

  1. Chassaing B , Aitken J D , Malleshappa M , et al. Dextran Sulfate Sodium (DSS)-Induced Colitis in Mice.[J]. Curr Protoc Immunol, 2014, 104:Unit 15.25.


Related Sections

Disease Models:

Inflammation & Autoimmune Disease Models:

Inflammatory Bowel Disease Models:

Customer Support & Price Inquiry
Please input "bioarray" as verification code.
CONTACT US USA
45-1 Ramsey Road, Shirley, NY 11967, USA
Tel: 1-631-626-9181
Fax: 1-631-614-7828
Email: 

Europe
Tel: 44-208-144-6005
Email: