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Immuno-Oncology

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Immuno-Oncology

Immuno-Oncology (I-O) is an emerging and evolving treatment modality that includes immunotherapies designed to utilize the body’s own immune system to fight diseases. The last 30 years of I-O research has progressed considerably with approvals for the use of various I-O therapies including vaccines, cytokines, tumor-directed monoclonal antibodies, and immune checkpoint inhibitors.

The immune system is the body’s natural defence system, which has the greatest potential for the specific destruction of infections, cancer and other diseases, with no toxicity to normal tissue and for long-term memory that can prevent recurrence. Scientists worldwide have been studying the relationship between the immune system and cancer therapy for several decades. Since cancer cells are very different from normal cells in the body, the immune system attacks them when it is able to recognize them. However, cancer cells often find ways to disguise themselves as normal cells, so that the immune system does not always recognize them as dangerous. In addition, similar to viruses, they can change over time (mutate) and therefore escape from the immune response. The process by which the immune system recognizes, destroys, and sculpts tumors is known as follows:

Immuno-Oncology

Immuno-oncology therapy can activate body’s immune system, making it able to recognize cancer cells and destroy them. I-O therapies have the potential to provide lasting anti-cancer benefits to patients who previously had very few treatment options available to them. There is also a potential for enhanced antitumor activity in combining I-O therapies with other cancer treatment modalities.

Creative Bioarray possesses a research team, which has been focused on Immune-Oncology for decades. Since there are still lots of incomplete scientific understanding of tumor immunology, which gives rise to little widespread use of I-O therapies in clinic, Creative Bioarray is always ready to help and cooperate with customers on their I-O research or preclinical experiment.

With multitudinous tumor cells, diverse animal tumor models, and various tumor research related services, such as cell cycle assays, apoptosis assays, proliferation assays, migration assays and toxicology assays, Creative Bioarray could offer professional design and experiment for customers to facilitate their I-O program.

Advantages

  • Targeting the body’s immune system, not the tumor itself
  • Enabling the immune system to selectively recognize and attack cancer cells
  • Giving long-lasting memory to the immune system
  • Providing durable, long-term response to the cancer

Immuno-oncology framework

The immuno-oncology framework provides a set of methodological improvements for the development of cancer immunotherapies.

Immuno-Oncology

Applications

  • Understanding immunity to cancer
  • Enabling a new era of cancer therapy
  • Researching new target and developing new immune pharmaceutical

Study examples

Immuno-Oncology

Fig.1 Combinatorial anti–LAG-3/anti–PD-1 treatment inhibits tumor growth

Immuno-Oncology

Fig.2 Combinatorial anti–LAG-3/anti–PD-1 treatment results in enhanced adaptive immune responses

Quotation and ordering

If you have any special needs in Immuno-Oncology research, please contact us at or 1-631-626-9181 for this special service. Let us know what you need and we will accommodate you. We look forward to working with you in the future.

References

1.Seng-Ryong Woo.; et al. Immune Inhibitory Molecules LAG-3 and PD-1 Synergistically Regulate T-cell Function to Promote Tumoral Immune Escape. Cancer Res. 2011, 72(4): 917–927.
2.Jennifer Couzin-Frankel. Cancer immunotherapy. Science. 2013, 342(6165): 1432-1433.
3.Antonia S.J.; et al. Immuno-oncology combinations: a review of clinical experience and future prospects. Clin Cancer Res. 2014, 20(24): 6258–6268.
4.Hoos A.; Britten C. M. The immuno-oncology framework. OncoImmunology. 2012, 1(3): 334-339.

Related Sections

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