Toxicokinetics & Pharmacokinetics
The study of toxicokinetics and pharmacokinetics plays a crucial role in drug development and safety assessment. Creative Bioarray offers a wide range of related resources, which allow researchers to evaluate the pharmacokinetic properties of drugs and assess their potential toxicity.
Toxicokinetics vs. Pharmacokinetics
Tag: TK and PK
Details: TK is defined as the generation of PK data, either as an integral component in the conduct of nonclinical toxicity studies or in specifically designed supportive studies to assess systemic exposure.
Parameters of Pharmacokinetics: Absorption, Distribution, Metabolism, Excretion
Tag: PK parameters
Details: Pharmacokinetics encompasses the study of drug disposition within the body, which involves several key parameters, including absorption, distribution, metabolism, and excretion.
Physical and Chemical Properties of Drugs and Calculations
Tag: Drug properties
Details: In the realm of drug discovery and development, it is imperative to comprehend the physical and chemical attributes of drugs to refine their pharmacokinetic and pharmacodynamic properties.
Predictive Modeling of Metabolic Drug Toxicity
Tag: Drug toxicity
Details: Predicting the potential toxicity of new drug candidates is a critical step in the drug discovery and development process.
Experimental Methods for Identifying Drug-Drug Interactions
Tag: Drug-drug interactions
Details: Metabolism-mediated drug-drug interactions can significantly affect drug efficacy and safety, and thus it is imperative to identify and comprehend them during the drug development phase.
Effects of Cytochrome P450 Metabolism on Drug Interactions
Tag: Drug-drug interactions
Details: Cytochrome P450 enzymes can be inhibited or induced by drugs, resulting in clinically significant drug-drug interactions that can cause unanticipated adverse reactions or therapeutic failures.
Overview of In Vitro Permeability Assays
Tag: DMPK
Details: The importance of in vitro permeability assays lies in their ability to assess the ability of drug compounds to permeate cellular and tissue barriers, such as the intestinal epithelium or the blood-brain barrier.
Methods of Parallel Artificial Membrane Permeability Assays
Tag: DMPK
Details: Through various methods, PAMPA has been employed to assess gastrointestinal permeability (GIT-PAMPA), skin permeability (skin-PAMPA), and blood-brain barrier permeability (BBB-PAMPA).
Organoids in Drug Discovery: Revolutionizing Therapeutic Research
Tag: Drug discovery
Details: Organoids provide a powerful tool for studying human biology and disease in a more physiologically relevant and predictive manner.
Unraveling the Role of hERG Channels in Drug Safety
Tag: Drug toxicity
Details: In the realm of drug discovery and development, the assessment of hERG (human Ether-à-go-go-Related Gene) channel toxicity plays a vital role.
