Toxicokinetics & Pharmacokinetics
The study of toxicokinetics and pharmacokinetics plays a crucial role in drug development and safety assessment. Creative Bioarray offers a wide range of related resources, which allow researchers to evaluate the pharmacokinetic properties of drugs and assess their potential toxicity.
When Should You Introduce ADME Tox Testing in Drug Development?
Tag: ADME
Details: A stage-based ADME-Tox strategy highlighting key risk signals and integrated safety, PK, and potency insights to support better development decisions.
Top 5 Pitfalls in In Vitro ADME Assays and How to Avoid Them
Tag: ADME
Details: In vitro ADME assays are key to early drug discovery-but poor design can mislead project decisions. Learn the five critical pitfalls, from model selection to concentration choices, and see how to turn your ADME data into actionable insights.
In Vitro ADME vs In Vivo ADME
Tag: ADME
Details: A concise comparison of in vitro and in vivo ADME studies, explaining their respective roles, limitations, and how to use them together to support confident drug development decisions.
How to Choose the Right In Vitro ADME Assays for Small-Molecule Drugs
Tag: ADME
Details: A practical guide to selecting the right in vitro ADME assays for small-molecule drug discovery, aligned with development stage, physicochemical properties, and translational decision-making.
What Is Genotoxicity in Pharmacology? Mechanisms and Sources
Tag: Genotoxicity
Details: Explore the molecular mechanisms behind genotoxicity and understand why assessing genetic risk is essential for safe drug discovery.
How Genotoxicity Testing Guides Safer Drug Development
Tag: Genotoxicity
Details: A practical overview of genotoxicity assays, regulatory considerations, and data interpretation for researchers and drug developers.
From Cells to Systems: Modern Approaches to Disease Modeling
Tag: Disease model
Details: An overview of disease modeling strategies, applications, and major challenges in preclinical research.
What Are the Best Methods to Test Cardiotoxicity?
Tag: Cardiotoxicity
Details: Explore the most widely used cardiotoxicity testing methods—including in vitro assays, in vivo models, and advanced imaging.
Why Cardiotoxicity Matters in R&D?
Tag: Cardiotoxicity
Details: Discover what cardiotoxicity is, the key biological mechanisms behind it, and why evaluating cardiotoxic risks is essential in modern drug development and safety testing.
Key Considerations in Toxicokinetic
Tag: Toxicokinetic
Details: This article briefly explores toxicokinetics studies from aspects such as dose selection, matrix selection, choice of animal models, and sample collection
Organ-on-a-Chip Systems for Drug Screening
Tag: Drug Screening
Details: Organ-on-a-chip systems are poised to play an instrumental role in the future of drug screening by offering more reliable and comprehensive models of human physiology.
How to Improve the Pharmacokinetic Properties of Peptides?
Tag: PK
Details: An array of strategies, such as amino acid substitution, side chain modifications, conjugation with polymers, modification of peptide termini, fusion to albumin, conjugation to the Fc portion of antibodies, stapled peptides, etc., have been employed to enhance the pharmacokinetic profiles of peptides.
Pharmacokinetics of Therapeutic Peptides
Tag: PK
Details: The pharmacokinetic profile of therapeutic peptides significantly influences their therapeutic efficacy and safety. Key aspects of peptide pharmacokinetics include absorption, distribution, metabolism, and elimination.
How to Improve Drug Distribution in the Brain
Tag: DMPK
Details: This article described various drug delivery and targeting strategies are currently being developed to enhance the transport and distribution of drugs into the brain.
Key Factors Influencing Brain Distribution of Drugs
Tag: DMPK
Details: The distribution of drugs can be significantly affected by distinct brain characteristics such as anatomy, physiological barriers, and cellular and biochemical composition.
What factors influence drug distribution?
Tag: DMPK
Details: Drug distribution depends upon a range of variables such as the drug’s physicochemical composition, circulation, tissue content and how the drug interacts with macromolecules in the body.
The Rise of In Vitro Testing in Drug Development
Tag: In Vitro Testing
Details: The landscape of drug development has evolved significantly over the past few decades, with in vitro testing becoming increasingly integral to the process.
How to Design and Synthesize Antibody Drug Conjugates?
Tag: Antibody Drug Conjugates
Details: Antibody-drug conjugates (ADCs) represent a significant advancement, merging the specificity of monoclonal antibodies with the potency of cytotoxic drugs.
Pharmacokinetics Considerations for Antibody Drug Conjugates
Tag: Antibody Drug Conjugates
Details: Understanding the pharmacokinetics (PK) of ADCs is crucial for optimizing their therapeutic efficacy while minimizing systemic toxicity.
Comparison of MDCK-MDR1 and Caco-2 Cell-Based Permeability Assays
Tag: In Vitro Permeability and Transporters
Details: Both MDCK-MDR1 and Caco-2 cell models have distinct advantages and limitations that impact their utility in drug discovery and development.