Toxicokinetics & Pharmacokinetics
The study of toxicokinetics and pharmacokinetics plays a crucial role in drug development and safety assessment. Creative Bioarray offers a wide range of related resources, which allow researchers to evaluate the pharmacokinetic properties of drugs and assess their potential toxicity.
What Are the Best Methods to Test Cardiotoxicity?
Tag: Cardiotoxicity
Details: Explore the most widely used cardiotoxicity testing methods—including in vitro assays, in vivo models, and advanced imaging.
Why Cardiotoxicity Matters in R&D?
Tag: Cardiotoxicity
Details: Discover what cardiotoxicity is, the key biological mechanisms behind it, and why evaluating cardiotoxic risks is essential in modern drug development and safety testing.
Key Considerations in Toxicokinetic
Tag: Toxicokinetic
Details: This article briefly explores toxicokinetics studies from aspects such as dose selection, matrix selection, choice of animal models, and sample collection
Organ-on-a-Chip Systems for Drug Screening
Tag: Drug Screening
Details: Organ-on-a-chip systems are poised to play an instrumental role in the future of drug screening by offering more reliable and comprehensive models of human physiology.
How to Improve the Pharmacokinetic Properties of Peptides?
Tag: PK
Details: An array of strategies, such as amino acid substitution, side chain modifications, conjugation with polymers, modification of peptide termini, fusion to albumin, conjugation to the Fc portion of antibodies, stapled peptides, etc., have been employed to enhance the pharmacokinetic profiles of peptides.
Pharmacokinetics of Therapeutic Peptides
Tag: PK
Details: The pharmacokinetic profile of therapeutic peptides significantly influences their therapeutic efficacy and safety. Key aspects of peptide pharmacokinetics include absorption, distribution, metabolism, and elimination.
How to Improve Drug Distribution in the Brain
Tag: DMPK
Details: This article described various drug delivery and targeting strategies are currently being developed to enhance the transport and distribution of drugs into the brain.
Key Factors Influencing Brain Distribution of Drugs
Tag: DMPK
Details: The distribution of drugs can be significantly affected by distinct brain characteristics such as anatomy, physiological barriers, and cellular and biochemical composition.
What factors influence drug distribution?
Tag: DMPK
Details: Drug distribution depends upon a range of variables such as the drug’s physicochemical composition, circulation, tissue content and how the drug interacts with macromolecules in the body.
The Rise of In Vitro Testing in Drug Development
Tag: In Vitro Testing
Details: The landscape of drug development has evolved significantly over the past few decades, with in vitro testing becoming increasingly integral to the process.
How to Design and Synthesize Antibody Drug Conjugates?
Tag: Antibody Drug Conjugates
Details: Antibody-drug conjugates (ADCs) represent a significant advancement, merging the specificity of monoclonal antibodies with the potency of cytotoxic drugs.
Pharmacokinetics Considerations for Antibody Drug Conjugates
Tag: Antibody Drug Conjugates
Details: Understanding the pharmacokinetics (PK) of ADCs is crucial for optimizing their therapeutic efficacy while minimizing systemic toxicity.
Comparison of MDCK-MDR1 and Caco-2 Cell-Based Permeability Assays
Tag: In Vitro Permeability and Transporters
Details: Both MDCK-MDR1 and Caco-2 cell models have distinct advantages and limitations that impact their utility in drug discovery and development.
How to Conduct a Bioavailability Assessment?
Tag: Bioavailability
Details: Bioavailability refers to the relative amount and speed with which a drug or other active substance reaches the systemic circulation and exerts its effect at the site of action after non-intravenous administration.
What are the Pharmacokinetic Properties of the Antisense Oligonucleotides？
Tag: PK properties
Details: Oligonucleotide therapeutics are a class of nucleic acid-based treatments that exert therapeutic effects by binding to specific RNA or DNA molecules, thereby regulating gene expression or modifying gene activity.
What Are Metabolism-Mediated Drug-Drug Interactions?
Tag: Drug-drug interactions
Details: When two or more drugs are co-administered, their metabolic pathways can intersect, leading to a phenomenon known as metabolism-mediated drug-drug interactions (MMDDIs).
What Are Compartment Models in Pharmacokinetics?
Tag: PK
Details: PK models can range in complexity from models with a single compartment to models containing hundreds of compartments.
How Is the Cytotoxicity of Drugs Determined?
Tag: Drug cytotoxicity
Details: Cytotoxicity assays are a quick way to assess a certain chemical compound’s effects on a given human cell line. Cytotoxicity experiments are a crucial part of the modern pharmaceutical development process.
What Is the Role of the Blood-Brain Barrier in Drug Delivery?
Tag: Drug delivery
Details: The blood-brain barrier (BBB) is a highly selective and impermeable barrier that separates the circulatory system from the brain and the central nervous system (CNS).
Traditional vs. Novel Drug Delivery Methods
Tag: Drug delivery
Details: Effective drug delivery is the cornerstone of modern pharmaceutical science, ensuring that therapeutic agents reach their intended targets within the body while minimizing adverse effects and optimizing therapeutic efficacy.