Toxicokinetics & Pharmacokinetics
The study of toxicokinetics and pharmacokinetics plays a crucial role in drug development and safety assessment. Creative Bioarray offers a wide range of related resources, which allow researchers to evaluate the pharmacokinetic properties of drugs and assess their potential toxicity.
What factors influence drug distribution?
Tag: DMPK
Details: Drug distribution depends upon a range of variables such as the drug’s physicochemical composition, circulation, tissue content and how the drug interacts with macromolecules in the body.
What are the Pharmacokinetic Properties of the Antisense Oligonucleotides?
Tag: PK properties
Details: Oligonucleotide therapeutics are a class of nucleic acid-based treatments that exert therapeutic effects by binding to specific RNA or DNA molecules, thereby regulating gene expression or modifying gene activity.
How to Conduct a Bioavailability Assessment?
Tag: Bioavailability
Details: Bioavailability refers to the relative amount and speed with which a drug or other active substance reaches the systemic circulation and exerts its effect at the site of action after non-intravenous administration.
Toxicokinetics vs. Pharmacokinetics
Tag: TK and PK
Details: TK is defined as the generation of PK data, either as an integral component in the conduct of nonclinical toxicity studies or in specifically designed supportive studies to assess systemic exposure.
Parameters of Pharmacokinetics: Absorption, Distribution, Metabolism, Excretion
Tag: PK parameters
Details: Pharmacokinetics encompasses the study of drug disposition within the body, which involves several key parameters, including absorption, distribution, metabolism, and excretion.
Physical and Chemical Properties of Drugs and Calculations
Tag: Drug properties
Details: In the realm of drug discovery and development, it is imperative to comprehend the physical and chemical attributes of drugs to refine their pharmacokinetic and pharmacodynamic properties.
Predictive Modeling of Metabolic Drug Toxicity
Tag: Drug toxicity
Details: Predicting the potential toxicity of new drug candidates is a critical step in the drug discovery and development process.
Experimental Methods for Identifying Drug-Drug Interactions
Tag: Drug-drug interactions
Details: Metabolism-mediated drug-drug interactions can significantly affect drug efficacy and safety, and thus it is imperative to identify and comprehend them during the drug development phase.
Effects of Cytochrome P450 Metabolism on Drug Interactions
Tag: Drug-drug interactions
Details: Cytochrome P450 enzymes can be inhibited or induced by drugs, resulting in clinically significant drug-drug interactions that can cause unanticipated adverse reactions or therapeutic failures.
Overview of In Vitro Permeability Assays
Tag: DMPK
Details: The importance of in vitro permeability assays lies in their ability to assess the ability of drug compounds to permeate cellular and tissue barriers, such as the intestinal epithelium or the blood-brain barrier.
Methods of Parallel Artificial Membrane Permeability Assays
Tag: DMPK
Details: Through various methods, PAMPA has been employed to assess gastrointestinal permeability (GIT-PAMPA), skin permeability (skin-PAMPA), and blood-brain barrier permeability (BBB-PAMPA).
Organoids in Drug Discovery: Revolutionizing Therapeutic Research
Tag: Drug discovery
Details: Organoids provide a powerful tool for studying human biology and disease in a more physiologically relevant and predictive manner.
Unraveling the Role of hERG Channels in Drug Safety
Tag: Drug toxicity
Details: In the realm of drug discovery and development, the assessment of hERG (human Ether-à-go-go-Related Gene) channel toxicity plays a vital role.
Comparison of MDCK-MDR1 and Caco-2 Cell-Based Permeability Assays
Tag: In Vitro Permeability and Transporters
Details: Both MDCK-MDR1 and Caco-2 cell models have distinct advantages and limitations that impact their utility in drug discovery and development.
Pharmacokinetics Considerations for Antibody Drug Conjugates
Tag: Antibody Drug Conjugates
Details: Understanding the pharmacokinetics (PK) of ADCs is crucial for optimizing their therapeutic efficacy while minimizing systemic toxicity.
How to Design and Synthesize Antibody Drug Conjugates?
Tag: Antibody Drug Conjugates
Details: Antibody-drug conjugates (ADCs) represent a significant advancement, merging the specificity of monoclonal antibodies with the potency of cytotoxic drugs.
The Rise of In Vitro Testing in Drug Development
Tag: In Vitro Testing
Details: The landscape of drug development has evolved significantly over the past few decades, with in vitro testing becoming increasingly integral to the process.