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Human skin pigmentation is related to the metabolic activity of a lineage of cells known as melanocytes. Melanocytes extend dendrites from the cell body and create contact with the surrounding keratinocytes. Melanocytes produce the pigment melanin and transfer it via their dendritic processes to keratinocytes. Within melanocytes, melanin synthesis occurs in specialized membrane-bound organelles termed melanosomes, characterized by four stages of maturation along with they gradually become pigmented. Disturbances of its synthesis lead to abnormal pigmentation of the skin (lack of skin pigmentation or skin patches).
In cosmetic field, biologically active substances of skin whitening, contrast to skin pigmentation, with scientifically proven efficacy are already among the stars of the market for skin care ingredients. Skin whitening products are popular that are used not only to overall lighten skin tone, but also to reduce hyperpigmentation caused by skin ageing. In vitro safety and efficacy testing of skin whitening agents becomes increasingly important for cosmetics and dermatological industries.
In vitro 3D Pigmented Skin Model available
Histological characterization revealed that our model had a similar morphology as normal human skin, expressed keratinocyte differentiation as well as basement membrane markers, and showed a high degree of pigmentation.
Fig. 1 Fontana-Masson stain of melanosomes
Efficacy and Screening Tests available
Fig. 2 A) Melanin quantification; B) TYR expression
Fig. 3 Tyrosinase activity inhibition by a tested compound
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In vitro Skin Models: