Schizophrenia Model

Creative Bioarray has validated the Schizophrenia Model, a gold-standard preclinical tool for studying NMDA receptor hypofunction, a key mechanism underlying schizophrenia. By selectively blocking NMDA receptors, MK-801 replicates core behavioral and neurochemical hallmarks of the disorder, facilitating a robust evaluation of novel therapeutics targeting positive symptoms (e.g., hyperlocomotion, sensory gating deficits), negative symptoms (e.g., social withdrawal), and cognitive impairments (e.g., working memory deficits). We offer comprehensive efficacy evaluation services utilizing this model to support your therapeutic development efforts.

Creative Bioarray's Schizophrenia Model

Available Animal

• Mouse

Modeling Method

• Mice are administered a single intraperitoneal injection of MK-801 to induce a schizophrenia-like phenotype.

Fig. 1: Modeling method of MK-801-Induced Schizophrenia in Creative Bioarray

Endpoints

• Behavioral tests: Open field test
• Other customized endpoints

Example Data

Fig. 2: MK-801 caused schizophrenia-like behaviors in mice. (Huang et al., 2022)

Quotation and ordering

If you have any doubts about our services, please do not hesitate to get in touch with us. Let us know how we can work with you to make some new advances in schizophrenia.

Reference

1. Huang, X., et al. Activation of basolateral amygdala to anterior cingulate cortex circuit alleviates MK-801 induced social and cognitive deficits of schizophrenia. Frontiers in Cellular Neuroscience, 2022, 16: 1070015.