Migraine Models

If you are looking for a partner to help you evaluate the efficacy of your test compounds on migraine, Creative Bioarray is the best choice for you. Our expertise in migraine modeling allows us to tailor our services to meet the unique needs of each client, ensuring that their drug candidates are thoroughly evaluated. With our service, you can trust that your investment in drug development will be supported by high-quality, reliable data that can guide your decision-making process.

Migraine is a recurrent, debilitating neurological condition characterized by severe headaches often accompanied by a constellation of unpleasant symptoms. Impacting approximately 15% of the global population, migraine significantly diminishes the quality of life of its sufferers, imposing a considerable societal and economic burden. The migraine episode is typically divided into four distinct phases: the premonitory phase, the aura phase, the headache phase, and the postdromal phase. While these phases may occur in sequence, they can also exhibit substantial overlap.

Extensive research has elucidated that the trigeminovascular system, a critical component in migraine pathophysiology, is regulated by the brainstem and diencephalic nuclei. This system consists of efferent neurons that innervate vascular networks and afferent neurons that relay sensory information to the trigeminal nucleus caudalis. The activation of these neural networks results in meningeal inflammation and vasodilation, contributing to the perception of head pain during migraine episodes. This understanding of migraine's underlying mechanisms has paved the way for the development of targeted therapies aimed at alleviating the symptoms and reducing the frequency of migraine attacks.

Diagram illustrating the mechanisms of various phases of migraineFig. 1 The mechanisms of the different phases of migraine. An overlap of the different phases is possible. (Khan, J., et al, 2021)

Our Animal Models of Migraine

At Creative Bioarray, we offer a diverse range of migraine models designed to accurately assess the potential efficacy of our clients' drug candidates. Our commitment to scientific rigor and our dedication to providing reliable and reproducible results ensure that our clients can trust the outcomes of their studies. Our team of experienced scientists and state-of-the-art facilities allow us to offer a variety of models, including but not limited to:

Quotation and Ordering

As a premier Contract Research Organization (CRO) specializing in drug development, Creative Bioarray is committed to delivering dependable and cost-efficient services tailored to meet the needs of our clients. If you are interested in our services, please feel free to contact us at any time or submit an inquiry to us directly. We look forward to cooperating with you.


  1. Khan, J., et al. Genetics, pathophysiology, diagnosis, treatment, management, and prevention of migraine. Biomedicine & Pharmacotherapy, 2021, 139: 111557.

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