Left Coronary Artery Ligation Model
Coronary heart disorder is the main cause of cardiovascular disease. Its main pathologic features include the occlusion of coronary artery caused by atherosclerotic plaques and thrombosis, which can result in myocardial infarction as well as heart failure. Simultaneously, reperfusion of occluded artery further lead to the injury of ischemic myocardial tissue.
Left Coronary Artery Ligation is a reproducible model used in research of coronary heart disorder, ischemia reperfusion injury, myocardial infarction and arrhythmia as well as the targeted treatment strategies against these diseases. Creative Bioarray specializes in providing customized pharmacodynamic research services to help customers assess the efficacy of drug candidates and study the associated pathological mechanisms through left coronary artery ligation model.
Species available
- Rat
Our capabilities
- We screen novel test compounds targeting cardiovacular diseases.
- We collect the serum of different groups and detect the activities of myocardial enzymes and release of inflammatory mediators.
- We evaluate the degree of myocardial infarction using HE staining.
Assays available
- PK/PD collection
- Pathological evaluation
- Cytokine analysis
- ECG
With extensive experience in the field of cardiovacular diseases, we are confident to help you to overcome any upcoming challenges. Our experts are fully capable of customizing our protocols and assays to meet your specific needs. With our help, we wish to facilitate your research with high efficiency.
Study examples
Figure. 1. Quantification of the extent of infarct following LAD occlusion surgery.
Quotation and ordering
If you have any special needs or questions regarding our services, please feel free to contact us. We look forward to cooperating with you in the future.
Reference
Stujanna E N, et al. Rev-erb agonist improves adverse cardiac remodeling and survival in myocardial infarction through an anti-inflammatory mechanism[J]. PLoS ONE, 2017, 12(12):e0189330.
