Acute Spinal Cord Injury (ASCI) Model
Creative Bioarray, a leading contract research organization, has developed a robust and reliable model to study acute spinal cord injury (ASCI) and evaluate the efficacy of potential therapeutics. The ASCI model serves as a cutting-edge platform for the development of innovative therapies to help individuals suffering from this debilitating condition. Our focus on developing such therapies demonstrates our commitment to improving the lives of patients and advancing the field of medical research.
Acute spinal cord injury (ASCI) is a devastating condition caused by a traumatic injury that bruises, partially tears, or completely tears the spinal cord. It is a common cause of permanent disability and even death in both children and adults. The consequences of ASCI are far-reaching, not only leading to decreased life expectancy and disability but also imposing an enormous financial burden on affected families and society at large. To better understand the underlying mechanisms of ASCI and evaluate the efficacy of experimental therapeutic interventions, ASCI animal model has proved to be invaluable in scientific research.
Our Acute Spinal Cord Injury (ASCI) Model
- Modeling Method
Creative Bioarray uses the controlled impact device to induce contusion to create the ASCI model. - Available Animal
- Rat
- Mouse
- Group Setting
- Sham group
- Model group
- Three dose groups of the test compound
- Endpoints
- Basso-Beattie-Bresnahan (BBB) score
- Histology analysis (spinal cord): H&E staining, IHC
- Mechanical allodynia test
- Behavioral tests
- qPCR and Western Blot
- Other customized endpoints: available upon request
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Fig. 1 Workflow of our ASCI model
Example Data
Fig. 2 BBB score decreases in the ASCI rat model group and PMS improves the BBB score of ASCI rats
Fig. 3 Plantamajoside alleviates the pathological morphology of the spinal cord in rats
Quotation and Ordering
As a leading provider of contract research services for in vivo pharmacology across various disease areas, Creative Bioarray offers dependable and cost-effective study solutions, leveraging either our well-established models or novel ones. Furthermore, we are committed to personalizing and adapting all studies to align with our clients' unique requirements. If you are interested in our services, please do not hesitate to contact us. We are looking forward to cooperating with you now!
Reference
- Hu, H., Jian, X. The protective mechanism of action of plantamajoside on a rat model of acute spinal cord injury. Experimental and Therapeutic Medicine, 2021, 21(4): 1-7.
