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The potential of chemicals to induce skin irritation is an important consideration in establishing procedures for the safe handling, packing and transport of chemicals. Skin irritation testing becomes an important requisite of the preparation of pharmaceuticals and cosmetics. As an alternative to the animal-based Skin Irritation Test, Skin irritation potential can be predicted by in vitro systems, provided they are sufficiently complex to mimic skin barrier in vivo and cell reactivity.
Creative Bioarray provides in vitro systems for skin irritation assays including skin models and in vitro testing services to our customer utilized by the cosmetics, personal care, household products, chemical, pharmaceutical, and biotech industries.
Creative Bioarray's skin irriation test is preformed using our or the customer's Reconstructed human epidermis (RHE) based on the OECD Test guidelines 439 which were published in 2010. Creative Bioarray follows the standardised skin irritation test procedure within the OECD guidelines.
Fig1. Cell viability measured by MTT assay after treatment of cells with different compounds.
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In vitro Skin Models: