Liver Disease Models

Liver diseases occur frequently and are life-threatening for humans. The underlying causes vary from viral infections, autoimmune diseases and intoxications (including alcohol abuse) to unbalanced diets. Although the liver can regenerate without injury in the early stages of the disease, it cannot heal in the later stages and may require an organ transplant. We must understand the underlying mechanisms in order to design and develop new drugs in this area. Mature and stable animal models to mimic human liver diseases could thus play an important role.

Creative Bioarray established a variety of animal models for liver diseases, including acute liver injury, chronic liver injury, chronic fatty liver disease, alcoholic steatohepatitis (ASH) and nonalcoholic steatohepatitis (NASH). These models have unique characteristics and etiologies of human liver diseases to help clients assess the efficacy of new compounds in related clinical liver diseases and better understand the underlying mechanisms of new drugs.

Our portfolio of liver disease models cover the following diseases

  • Acute liver injury

    Alcohol/CCI4 induced acute liver injury models in rodents

  • Chronic liver injury

    CCl4/BDL induced liver fibrosis models in rodents

    CCl4 induced liver cirrhosis models in rodents

  • Chronic fatty liver disease

    HFD-induced fatty liver in rodents

  • Alcoholic steatohepatitis (ASH) & non-Alcoholic steatohepatitis (NASH)

We support R&D of new compounds, with various endpoints

  • Physical observation and examination
  • Biomarker analysis

    PCR, ELISA, Western Blot, Serum ALT/AST analysis

  • Histology analysis

    H&E staining, Masson staining, Sirius red staining

Data & Figures

Liver Disease Models Figure.1 HE and masson staining of NASH model

Quotation and ordering

We have extensive experience in developing disease models based on scientific publications. To discuss any of these models further or to discuss the possibility of developing alternative models, please do not hesitate to contact us.


  1. Liu, Y. et al. Animal models of chronic liver diseases. Am. J. Physiol. Gastrointest. Liver Physiol. 304, G449-468 (2013).

For research use only. Not for any other purpose.