Humanized PBMC Mouse Models

Creative Bioarray has developed highly stable, humanized peripheral blood mononuclear cell (PBMC) mouse models that are seamlessly compatible with both Cell Line-Derived Xenograft (CDX) and Patient-Derived Xenograft (PDX) models. These advanced models serve as invaluable tools in assessing the efficacy of our clients' test compounds. Our expertise in crafting PBMC humanized mouse models underscores our dedication to delivering reliable and cutting-edge solutions for preclinical research, ensuring that our customers can confidently evaluate the therapeutic potential of their compounds within a highly relevant in vivo system. With Creative Bioarray, you can anticipate unparalleled support and innovative approaches throughout your drug development journey.

Incorporating human immune cells into in vivo models is crucial for advancing research in cancer therapy, and the study of tumor immunity. The process of humanizing mice, particularly through the use of PBMCs, is of significant interest due to the ease and speed with which these cells can be implanted into immunodeficient mice. This approach results in the rapid engraftment of human immune cells, creating a PBMC-humanized mouse model that offers a cost-effective solution for short-term oncology studies.

Our Humanized PBMC Mouse Models

As a leading innovator in the field of humanized immune system models, Creative Bioarray offers a diverse array of sub-platforms tailored to meet the specific needs of our customers. According to different application, we provide the following specialized models:

Fig. 1 Workflow of establishing humanized PBMC mouse models.

Key Advantages

Creative Bioarray has conducted extensive research and iteration on the PBMC model to develop stable humanized PBMC mouse models with the following advantages:

Fig. 2 Advantages of humanized PBMC mouse models in Creative Bioarray.

Example Data

Fig. 3 Effect of immune checkpoint inhibitors on body weight and tumor volume in mice reconstructed with human peripheral blood mononuclear cell-derived T cells.

Quotation and Ordering

Creative Bioarray has successfully developed stable humanized PBMC mouse models to significantly aid in your oncology research endeavors. We also offer bespoke humanized mouse models, meticulously designed to assess the efficacy of your innovative anti-cancer agents or cancer immunotherapies. If you are interested in our services, please feel free to contact us at any time or submit an inquiry to us directly.