Gastric Tumor Cells

Gastric cancer is a highly heterogeneous malignancy with diverse histological and molecular profiles. As a leading cause of cancer-related mortality worldwide, understanding its complex biology—from H. pylori-induced transformation to advanced metastasis—requires physiologically relevant in vitro models.

Our Gastric Tumor Cell line collection encompasses a broad spectrum of models, including the classic Lauren classification (Intestinal and Diffuse types) and various molecular subtypes. These cell lines serve as essential tools for studying gastric mucosal barriers, epithelial-to-mesenchymal transition (EMT), and the development of targeted therapies.

High-Purity Phenotypically Diverse Well-Characterized Expert-Supported

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Key Features & Expertise

Our gastric tumor cell lines are distinguished by their comprehensive biological relevance and rigorous validation:

Diverse Histological Representation

Includes well, moderately, and poorly differentiated Gastric Adenocarcinomas.
Specialized models for Signet Ring Cell Carcinoma and Mucinous Adenocarcinoma.
Derived from various anatomical sites, including the antrum, body, and cardia, as well as metastatic sites like the liver and lymph nodes.

Advanced Molecular Profiling

Defined HER2/neu expression levels for targeted drug screening and resistance studies.
Models with documented EBV (Epstein-Barr Virus) and MSI (Microsatellite Instability) status.
Genomic data available for key mutations, including TP53, CDH1 (E-cadherin), and PIK3CA.

Uncompromising Quality Control

Authenticated via STR profiling to ensure genetic consistency and eliminate cross-contamination.
Guaranteed Mycoplasma-free and tested for bacterial/fungal sterility.
Optimized protocols provided for growth kinetics, media requirements, and cryopreservation.

FAQ

How do I choose the best gastric cancer cell line for HER2 research?

For studies involving HER2-targeted therapies (like Trastuzumab), NCI-N87 is a widely recognized model due to its high HER2 amplification. We provide specific expression data to help you select the most relevant model for your assay.

Do you provide normal gastric epithelial cells as experimental controls?

Yes. To ensure robust comparative data, we offer immortalized human gastric mucosal epithelial cell lines, which are essential for identifying tumor-specific changes in gene expression and drug response.

Are these cell lines suitable for studying drug resistance?

Absolutely. Our collection includes lines with varying sensitivities to standard chemotherapeutics like 5-Fluorouracil (5-FU), Cisplatin, and Taxanes. We also offer specific multidrug-resistant (MDR) variants for specialized research.

Can these cells be used for in vivo xenograft studies?

Many of our gastric tumor lines are highly tumorigenic and well-suited for subcutaneous or orthotopic xenograft models in nude mice, allowing for the translation of in vitro findings into complex biological systems.

What information is provided regarding the EBV status of the cell lines?

Since EBV-associated gastric cancer represents a distinct molecular subtype, we provide data on the EBV infection status for relevant lines, enabling researchers to study virus-host interactions in gastric carcinogenesis.

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