In Vivo Pharmacokinetics & Bioanalysis Services
- Overview
- Services
- Features
- FAQ
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Understanding the pharmacokinetic (PK) and toxicokinetic (TK) profiles of drug candidates is essential for de-risking development and guiding data-driven decision-making in the preclinical stage. At Creative Bioarray, we offer a comprehensive portfolio of in vivo PK studies and bioanalytical services designed to characterize absorption, distribution, metabolism, and excretion (ADME) properties, as well as to establish clear exposure–response relationships. Our integrated approach enables robust evaluation of systemic exposure, supports efficacy and safety assessments, and accelerates the transition from discovery to IND-enabling studies.
Service Offerings
Pharmacokinetic and Toxicokinetic Studies
We conduct full PK and TK profiling across multiple species to assess absorption, distribution, metabolism, and excretion (ADME). Our studies help determine drug exposure, half-life, clearance, and safety margins, ensuring optimal dosing strategies for preclinical and clinical trials.
We combine PK/PD modeling with biomarker analysis to establish exposure–response relationships, supporting dose optimization and translational research.
Bioavailability and Bioequivalence Studies
Our BA/BE services evaluate the rate and extent of drug absorption under various administration routes and formulations, supporting both novel drug development and generic drug assessment.
We provide validated LC-MS/MS, HPLC, ELISA and other bioanalytical platforms for quantitative determination of drugs, metabolites, and biomarkers in various biological matrices.
Mass Balance, Excretion, and Expired Air Collection
We conduct radiolabeled and non-radiolabeled mass balance studies to track drug elimination pathways (urine, feces, bile). Our specialized expired air collection system detects volatile metabolites, providing a complete ADME profile.
Administration Routes and Biofluid Sampling
We support multiple drug administration routes (IV, PO, SC, IP, inhalation) and serial/sparse sampling from blood, urine, CSF, and tissues. Our flexible study designs ensure accurate PK profiling for diverse therapeutic candidates.
Why Choose Us?
Comprehensive Service Portfolio
From PK/TK studies to bioanalytical support, BA/BE evaluations, biomarker analysis, and mass balance studies, we provide an integrated solution across the entire preclinical drug development pipeline.
Extensive Animal Models
Broad coverage of rodent (mice, rats, guinea pigs) and non-rodent species (dogs, mini-pigs, non-human primates) to meet diverse regulatory and scientific requirements.
Flexible Dosing & Sampling
Multiple administration routes (oral, IV, SC, IP, inhalation, etc.) and biofluid sampling options (plasma, blood, urine, bile, CSF, expired air) tailored to specific program requirements.
Experienced Scientific Team
A multidisciplinary team with extensive expertise in PK/PD, toxicology, and bioanalysis ensures high-quality data interpretation and customized study solutions.
FAQ
What species do you support for PK and TK studies?
We offer studies in rodents (mice, rats, guinea pigs) and non-rodents (dogs, mini-pigs, non-human primates) to meet diverse research and regulatory needs.
What bioanalytical methods are available for quantifying drugs and biomarkers?
Our bioanalytical platforms include LC-MS/MS, HPLC, ELISA, and other validated methods for accurate quantification in plasma, urine, bile, CSF, and tissue samples.
What administration routes can you accommodate?
We support multiple routes including IV, oral, subcutaneous, intraperitoneal, and inhalation, with flexible dosing and sampling strategies tailored to study objectives.
How do you ensure data quality and compliance?
Our studies are designed and conducted by experienced scientists under strict quality standards, with validated bioanalytical methods that align with regulatory guidelines.
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