Osteoarthritis (OA) Model
If you are seeking a trusted CRO partner to assist you in evaluating the efficacy of your test compounds in the treatment of osteoarthritis, Creative Bioarray is the best choice for you. With our expertise in orthopedic research and a team of skilled scientists, we offer state-of-the-art osteoarthritis (OA) models tailored to meet your specific research needs. We pride ourselves on delivering accurate and reliable results, ensuring that you have the necessary data to make informed decisions in your drug discovery and development process.
OA is the most prevalent disease affecting movable joints, primarily targeting the knee, hip, and hands. Characterized by the progressive erosion of articular cartilage, OA is marked by increasing pain during joint movement and a decreasing ability for the joint to withstand mechanical stress. Over time, this condition restricts joint mobility and impairs its function. However, current OA treatments remain largely symptomatic, providing temporary relief from pain but falling short of preventing cartilage damage and the destruction of other joint tissues. Given this treatment gap, the OA disease model plays a crucial role. This model is a representation of the disease that simulates its pathogenesis, symptoms, and progression. It serves as a valuable tool for researchers to better understand OA's underlying mechanisms, evaluate the efficacy of potential therapeutic agents, and explore new treatment strategies.
Fig. 1 Classification of osteoarthritis models based on etiology in human equivalent being studied, primary OA and post-traumatic OA.
Our Animal Models of Osteoarthritis (OA)
To accurately replicate diverse aspects of human OA disease, Creative Bioarrayhas established a comprehensive range of models, including surgically- and chemically-induced rodent models. In addition, we also perform a number of assessments and customized study protocols that suit specific client needs.
Induced Models
- Monosodium Iodoacetate (MIA)-Induced Osteoarthritis (OA) Model
- Papain-Induced Osteoarthritis (OA) Model
Surgical Models
- Medial Meniscal Tear (MMT)-Induced Osteoarthritis (OA) Model
- Anterior Cruciate Ligament Transection (ACLT)-Induced Osteoarthritis (OA) Model
Quotation and Ordering
Backed by a team of highly skilled scientists and experts specializing in the field of orthopedic research, Creative Bioarray boasts an exceptional capacity to provide a comprehensive and fully integrated service. Our team is dedicated to delivering innovative and tailored solutions that cater to the diverse needs of orthopedic research. If you are interested in our services, please feel free to contact us at any time or submit an inquiry to us directly.
References
- Vinatier, C., et al. Osteoarthritis: from pathogenic mechanisms and recent clinical developments to novel prospective therapeutic options. Drug discovery today, 2016, 21(12): 1932-1937.
- Kuyinu, E.L., et al. Animal models of osteoarthritis: classification, update, and measurement of outcomes. Journal of orthopaedic surgery and research, 2016, 11: 1-27.
